PMID: 9166332May 1, 1997Paper

Diabetes insipidus in pregnancy: a treatable cause of oligohydramnios

Obstetrics and Gynecology
R S HansonL Larson

Abstract

Diabetes insipidus, which presents with polyuria, polydipsia, and profound electrolyte abnormalities, occurs rarely in pregnancy. We report a patient with severe oligohydramnios that resolved after treatment of diabetes insipidus. A 14-year-old girl was admitted at 33 weeks' gestation with cramping and vaginal spotting. A sonogram indicated oligohydramnios and an amniotic fluid index (AFI) of 2.6, with normal fetal kidneys and bladder. On hospital day 2, the AFI was 0.0. Recorded fluid was 8 L in and 13.6 L out. Serum sodium was 153 mEq/L. Diabetes insipidus was diagnosed and treated with intranasal desmopressin acetate. The oligohydramnios resolved rapidly, and the patient delivered a healthy 2700-g male infant at 38 weeks. Although rare, diabetes insipidus may present initially in pregnancy and should be considered in patients with oligohydramnios. Simple diagnosis with determination of 24-hour urine volume and serum electrolytes can identify this potentially reversible cause of oligohydramnios and poor obstetric outcome.

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Citations

Nov 11, 2003·Obstetrics and Gynecology·David M ShererOvadia Abulafia
May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Sonia Ananthakrishnan
Jan 27, 2007·Placenta·M H BeallM G Ross
Jun 17, 2000·Annals of Internal Medicine·K Rosene-MontellaR V Lee
Aug 3, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Jeong Woo ParkSang Youb Han
Feb 15, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D M Sherer, O Langer
Mar 17, 2021·BMJ Case Reports·Alexandra Novais AraújoMaria João Guerreiro Martins Bugalho
Apr 1, 2021·Curēus·Cody M MutterHoang Nguyen
Aug 18, 2021·Clinical Case Reports·Karin ImaizumiKeiya Fujimori

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