Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications

Pituitary
S TsagarakisI Dimopoulou

Abstract

Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The development of DI seems to correlate with the severity of trauma. In most occasions DI is transient, but persisting DI may develop with an incidence of 6.9-7.5% amongst TBI victims. The assessment of the adequacy of adrenal function during the acute phase of TBI remains a diagnostic challenge. A few studies demonstrated an incidence of hypoadrenalism of 15-16% during the early phase of TBI. It should be noted that early hypoadrenalism may be due to either a structural damage at the level of the hypothalamo-pituitary unit or it may develop in the context of the so-called "relative adrenal insufficiency", a functional abnormality that is currently increasingly recognized during the course of severe illness. Secondary hypoadrenalism during the late phases of TBI appears with an incidence of 7.1-12.7%. The "low-T3 syndrome" compromises the assessment of thyroid function during the acute phase of TBI; the incidence of TSH i...Continue Reading

References

Dec 11, 1976·The Journal of Trauma·J M GriffinW E Schatten
Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G DicksteinM Lahav
Sep 1, 1980·Neurology·P J SavinoN J Schatz
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·L J De Groot
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·S BenvengaF Trimarchi
Oct 14, 2000·Ryōikibetsu shōkōgun shirīzu·T Mitsuma, Y Hirooka
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·S A LiebermanR J Urban
Feb 21, 2003·The New England Journal of Medicine·Mark S Cooper, Paul M Stewart
Sep 27, 2003·Epilepsia·John Bruns, W Allen Hauser
Apr 16, 2004·The New England Journal of Medicine·Amir H HamrahianBaha M Arafah
Apr 24, 2004·Clinical Endocrinology·Amar AghaChristopher J Thompson
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Brent E Masel
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Dec 24, 2004·Current Opinion in Critical Care·Jack J M Ligtenberg, Jan G Zijlstra
Jan 8, 2005·Journal of Endocrinological Investigation·F F CasanuevaUNKNOWN Athens TBI and Hypopituitarism Study Group
Mar 11, 2005·European Journal of Endocrinology·Amar AghaChristopher J Thompson
May 10, 2005·European Journal of Endocrinology·Marta BondanelliEttore C degli Uberti

❮ Previous
Next ❯

Citations

Apr 2, 2008·Journal of Computer Assisted Tomography·Darlene D MakulskiFaye Y Chiou-Tan
Aug 5, 2015·Journal of Clinical Medicine·Josef Zihl, Osborne F X Almeida
Aug 5, 2015·Journal of Clinical Medicine·Cristina CapatinaNiki Karavitaki
Apr 6, 2012·Neuroscience and Biobehavioral Reviews·Esteban ToledoDavid Borsook
Apr 25, 2009·Immunology and Allergy Clinics of North America·Erica J DoczyJames P Herman
Sep 12, 2013·Medical Hypotheses·Theo DiamandisCesar V Borlongan
Nov 12, 2016·The Linacre Quarterly·Doyen Nguyen
Jul 23, 2011·The Journal of Craniofacial Surgery·Josephine J SungChristian A El-Amm
Apr 13, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Biff F PalmerAnthony J Bleyer
Jun 19, 2021·World Journal of Emergency Medicine·Gui-Long FengXiao Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Amar AghaChristopher J Thompson
European Journal of Endocrinology
Amar AghaChristopher J Thompson
Journal of Neurology, Neurosurgery, and Psychiatry
L A BehanAmar Agha
© 2021 Meta ULC. All rights reserved