Diabetes, insulin use and Helicobacter pylori eradication: a retrospective cohort study.

BMC Gastroenterology
Chin-Hsiao Tseng

Abstract

Diabetic patients may have a higher risk of gastric cancer. However, whether they have a higher incidence of Helicobacter pylori (HP) eradication is not known. Furthermore, whether insulin use in patients with type 2 diabetes may be associated with a higher incidence of HP eradication has not been investigated. This is a retrospective cohort study. The reimbursement databases from 1996 to 2005 of 1 million insurants of the National Health Insurance in Taiwan were retrieved. After excluding those aged <25 years, cases of gastric cancer, cases receiving HP eradication before 2005, patients with type 1 diabetes mellitus and those with unknown living region, the reimbursement data of a total of 601,441 insurants were analyzed. Diabetes status and insulin use in patients with type 2 diabetes before 2005 were the main exposures of interest and the first event of HP eradication in 2005 was the main outcome evaluated. HP eradication was defined as a combination use of proton pump inhibitor or H2 receptor blockers, plus clarithromycin or metronidazole, plus amoxicillin or tetracycline, with or without bismuth, in the same prescription for 7-14 days. The association between type 2 diabetes/insulin use and HP eradication was evaluated by ...Continue Reading

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Citations

Nov 5, 2013·World Journal of Gastroenterology : WJG·Shouji Shimoyama
Jul 4, 2013·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Jamshid VafaeimaneshMohammadreza Seyyedmajidi
Jul 19, 2012·Alimentary Pharmacology & Therapeutics·A G McNicholl, J P Gisbert
Sep 18, 2013·Helicobacter·Claire Roubaud BaudronAntonio Gasbarrini
Apr 29, 2014·Gastroenterology Research and Practice·Chao-Hung KuoLin-Li Chang
Jan 27, 2016·Journal of Pharmacy Practice·George K NimakoAlice C Ceacareanu
Jun 30, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Chin-Hsiao Tseng
Nov 22, 2012·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Chin-Hsiao Tseng, Farn-Hsuan Tseng
Jul 16, 2019·Minerva endocrinologica·Marina ValenzanoGiorgio Grassi
Apr 10, 2013·Expert Review of Anti-infective Therapy·Lyudmila Boyanova, Ivan Mitov
Nov 17, 2020·Frontiers in Endocrinology·Chin-Hsiao Tseng
Nov 17, 2020·Frontiers in Oncology·Chin-Hsiao Tseng

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