PMID: 26838193Feb 4, 2016Paper

Diabetes is an Important Risk Factor for Metastasis in Non- Muscle-Invasive Bladder Cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Kutan OzerEmin Ozbek

Abstract

Epidemiological evidence indicates that individuals with diabetes mellitus (DM) may have a modestly increased risk of bladder cancer. In the present study, we aimed to show any association between DM and risk of metastasis in patients with non-muscle-invasive bladder cancer (NMIBC). We retrospectively analyzed 698 patients between January 2007 and December 2014 who were diagnosed with and underwent transurethral resection of bladder tumors (TUR-BT). Comparisons of means was conducted by independent samples t test, and relations between categorical variables were investigated by non-parametric chi- square test. A p value of 0.05 was accepted as statistically significant in comparisons. We analyzed 418 patients with non muscle invasive bladder cancer. 123 of whom were diabetic and 295 non-diabetic. In diabetic patients, 13 were N1 stage and 11 M1 stage. When compared with non diabetic patients that was statistically significant (p<0.001). TNM stages were more advanced in diabetic patients (p<0.001), but concurrent CIS (p=0.1) and squamous metaplasia did not significantly differ between diabetic and non-diabetic cases (p=1). Diabetic patients with non-muscle-invasive bladder cancer may suffer metastases earlier than expected altho...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C D StilesW J Pledger
Nov 22, 1991·Science·S A Aaronson
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·P K Lipponen, M J Eskelinen
Jun 1, 1997·Journal of Pain and Symptom Management·J Poulson
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Nov 19, 2002·Cancer·Apeksha TripathiUNKNOWN Iowa Women's Health Study
Jun 12, 2004·American Journal of Epidemiology·Steven S CoughlinMichael J Thun
Nov 27, 2004·Cancer Immunology, Immunotherapy : CII·Ellen A M Schenk-Braat, Chris H Bangma
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Sun Ha JeeJonathan M Samet
Nov 3, 2005·Nature Clinical Practice. Oncology·Lisa C Richardson, Lori A Pollack
Oct 6, 2006·Diabetologia·S C LarssonA Wolk
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Susanna C LarssonAlicja Wolk
Apr 18, 2009·Current Opinion in Oncology·Carl J Bischoff, Peter E Clark
Jul 22, 2009·Endocrine-related Cancer·Paolo VigneriRiccardo Vigneri
Sep 22, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·J G BoyleG A McKay
Jun 29, 2011·Current Molecular Medicine·N RucciA Angelucci
Sep 15, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Eu Chang HwangSoo Bang Ryu
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Dec 20, 2013·International Journal of Molecular Sciences·Tao ZhangXunbo Jin
Mar 25, 2015·International Journal of Surgery Case Reports·Jeong Hee Hong

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