Diabetes mellitus after renal transplantation: as deleterious as non-transplant-associated diabetes?

A M MilesE A Friedman


Despite use of lower doses of corticosteroid hormones after renal allotransplantation in the era of cyclosporine and tacrolimus, posttransplant diabetes mellitus remains a common clinical problem. We prospectively investigated the effect of posttransplant diabetes on long-term (mean follow-up, 9.3+/-1.5 years) graft and patient survival in the 11.8% of our renal transplant population (n = 40) who developed diabetes after kidney transplantation, and we compared outcome in 38 randomly chosen nondiabetic control patients who had received transplants concurrently. Twelve-year graft survival in diabetic patients was 48%, compared with 70% in control patients (P = 0.04), and Cox's regression analysis revealed diabetes to be a significant predictor of graft loss (P = 0.04, relative risk = 3.72) independent of age, sex, and race. Renal function at 5 years as assessed by serum creatinine level was inferior in diabetic patients compared to control patients (2.9+/-2.6 vs. 2.0+/-0.07 mg/dl, P = 0.05). Two diabetic patient who experienced graft loss had a clinical course and histological features consistent with diabetic nephropathy; other diabetes-related morbidity in patients with posttransplant diabetes included ketoacidosis, hyperosmola...Continue Reading


Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·T Gauperaa, H Stalsberg
Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A von KiparskiU Binswanger
Aug 10, 1989·The New England Journal of Medicine·J ErikssonL Groop
Jan 1, 1985·American Journal of Nephrology·E A FriedmanK M Butt
Aug 31, 1974·Lancet·C M HillM G McGeown
Sep 1, 1980·The Journal of Clinical Investigation·Y KrauszG W Sharp

❮ Previous
Next ❯


Apr 28, 2010·Journal of General Internal Medicine·Gaurav GuptaPeggy B Hasley
Jun 3, 2005·Current Diabetes Reports·Moro O SalifuSamy I McFarlane
Jul 22, 2005·Current Diabetes Reports·Martha Pavlakis
Jul 31, 2009·Current Diabetes Reports·Vittoria BonatoMario Carmellini
Dec 31, 2003·Transplantation Proceedings·M KoseljA Kandus
Dec 31, 2003·Transplantation Proceedings·C R ParikhL Chan
Mar 12, 2004·Transplantation Proceedings·M C YağmurdurM Haberal
Mar 26, 2004·Transplantation Proceedings·B D Maes, Y F Ch Vanrenterghem
Aug 11, 2001·Transplantation Proceedings·G Viberti
Aug 11, 2001·Transplantation Proceedings·A V Reisaeter, A Hartmann
Aug 11, 2001·Transplantation Proceedings·M Markell
Aug 11, 2001·Transplantation Proceedings·P Marchetti
Aug 11, 2001·Transplantation Proceedings·J B ChilcottR Moore
Dec 26, 2001·Transplantation Proceedings·M KoseljA Bren
Feb 20, 2003·Transplantation Proceedings·R K SharmaA Kumar
Oct 8, 2003·Transplantation Proceedings·J WyzgalM Durlik
Mar 20, 1999·Transplantation Proceedings·C Legendre
Jul 3, 2003·Seminars in Nephrology·Arjang DjamaliJohn D Pirsch
Nov 16, 2011·Nature Reviews. Nephrology·Adnan Sharif, Keshwar Baboolal
May 2, 2002·Kidney International. Supplement·Emöke M Dimény
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Agnes Lo
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·Y F Vanrenterghem
Feb 16, 2006·Transplantation·Rebecca HobanMark D Pescovitz
Apr 25, 2007·Transplantation·Thomas E BurroughsMark A Schnitzler
Feb 28, 2008·Transplantation·Arthur J MatasRaja Kandaswamy
Apr 9, 2009·Transplantation·Jasper W L HartogStephan J L Bakker
Apr 1, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·E M YoshidaD N Landsberg
Dec 17, 2008·Nephrology·Kai Ming Chow, Philip Kam-Tao Li
Jun 19, 2008·Endocrine Journal·Ken KatoMasatsugu Hori
Apr 4, 2008·Journal of the American Society of Nephrology : JASN·Olwyn JohnstonJohn S Gill
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B Fellström

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.