Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation

Mediators of Inflammation
Mariana Mendes-Braz, Joilson O Martins

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery.

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Citations

Nov 14, 2019·Journal of Medicinal Food·María de Los Ángeles Fortis-BarreraGerardo Blancas-Flores
Aug 28, 2020·Anais Da Academia Brasileira De Ciências·Ahmet G AggulTuba Aydin
Oct 30, 2020·Frontiers in Cellular and Infection Microbiology·Guoqiang SunYao Cheng
Mar 9, 2021·Journal of Robotic Surgery·Aryan ModasiAlexander Rosemurgy
Aug 4, 2021·Journal of Complementary & Integrative Medicine·Licyanne Ingrid C LemosLucia Fatima C Pedrosa

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