Diabetes mellitus and the sensory neuron

Journal of Neuropathology and Experimental Neurology
C TothD W Zochodne

Abstract

Sensory neurons in diabetes may be primarily targeted by diabetes and their involvement may account for prominent sensory loss and pain in diabetic patients. Previous studies demonstrating evidence of excessive polyol flux, microangiopathy, and oxidative stress involving sensory axons and ganglia have been joined by more recent work demonstrating altered neuron phenotype, mitochondrial dysfunction, ion channel alterations, and abnormal growth factor signaling. As such, an interesting and unique panoply of molecular changes in primary sensory neurons has been identified in diabetic models. Insulin deficiency and subsequent changes in second messenger signaling may also play an important role in how sensory neurons respond to diabetes. Applying approaches to support sensory neurons in diabetes may be an important therapeutic direction in diabetic patients.

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Citations

Jan 13, 2009·Diabetes·George FrancisCory Toth
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·James M Kennedy, Douglas W Zochodne
Aug 24, 2010·Expert Review of Endocrinology & Metabolism·Paul FernyhoughRobert E Schmidt
Mar 10, 2012·Cellular and Molecular Neurobiology·Beatrice Mihaela RaduMihai Radu
Jun 11, 2017·Reviews in the Neurosciences·Tufan Mert
Feb 23, 2018·Annals of Neurology·Tim GodelPhilipp Bäumer
Feb 26, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M J BeyakD Grundy
Mar 14, 2018·Journal of Diabetes Investigation·Masaki Kobayashi, Douglas W Zochodne
Jul 3, 2015·International Journal of Radiation Biology·Tufan MertIsmail Gunay
Apr 21, 2006·Brain Research Bulletin·Surendra S Katyare, Samir P Patel
Mar 6, 2007·Neurobiology of Disease·Noor RamjiDouglas W Zochodne

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