Diabetes mellitus as a vaccine-effect modifier: a review.

Expert Review of Vaccines
Thomas VerstraetenBradford D Gessner

Abstract

Diabetes mellitus (DM) is a highly prevalent, chronic condition in adults worldwide. Little is known about the potential role of diabetes as an effect modifier of vaccine protective responses. We conducted a literature review of the immunogenicity, efficacy and effectiveness of immunization in individuals, in studies that compared subjects with DM (DM+) and without DM (DM-). We found few published studies, which were only for vaccines against hepatitis B, influenza, pneumococcal disease, or varicela zoster. Except for a consistent attenuation of the immune response to hepatitis B vaccine among DM+ individuals, we found little other consistent evidence for DM as an effect modifier of vaccine responses. There are substantial gaps in our knowledge of the impact of DM on the immune response to immunization or effect of vaccination.

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Citations

Jan 30, 2021·The Journal of Clinical Endocrinology and Metabolism·Stefania DispinseriLorenzo Piemonti
Jul 3, 2021·Viruses·Kristin B WigginsStacey Schultz-Cherry

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