Diabetes mellitus: biosensors for research and management

A P Turner, J C Pickup


The condition of diabetes mellitus is described with particular reference to the parameters that it would be desirable to monitor in order to improve management and understanding of the disease. Previous attention has largely focused on analysis of glucose, but many other intermediates of carbohydrate, fat and protein metabolism are deranged in diabetes and may be alternative measures of control. The need for laboratory analysers, self-monitoring, closed-loop devices and alarms are detailed and the problems associated with implantable sensors discussed. Progress in the development of biosensors is reviewed using glucose sensors as the main example. Electrochemical, optoelectronic and calorimetric approaches to sensing are considered and it is concluded that configurations based either on hydrogen peroxide detection or on mediated electron transfer are most likely to provide a raid route to in vivo monitoring. The extension of biosensor technology to tackle other important substrates is discussed, the principal hurdle to success being seen as the lack of long-term stability of the biological component.


Nov 1, 1986·Diabetologia·D J ClaremontJ C Pickup
Jan 1, 1987·Biosensors·P N Bartlett, R G Whitaker
Jan 1, 1987·Biosensors·B H van der Schoot, P Bergveld
Jan 1, 1995·Biosensors & Bioelectronics·E WilkinsB A Muggenburg
Jun 1, 1996·Medical Engineering & Physics·E Wilkins, P Atanasov
Apr 26, 2003·Biosensors & Bioelectronics·M VaralliAlessandro Poscia
Dec 1, 1996·Medical Engineering & Physics·P AtanasovE Wilkins
May 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·U Fischer
Oct 15, 1988·BMJ : British Medical Journal·J Pickup
Nov 25, 2011·Enzyme and Microbial Technology·Michael S CavesRobert B Freedman
Jan 1, 1987·Biosensors·L D WatsonC R Lowe
Jul 1, 1986·Journal of Biomedical Engineering·D J ClaremontJ C Pickup
Jun 2, 2015·Scientific Reports·Michail Kastellorizios, Diane J Burgess
Jun 26, 2014·Accounts of Chemical Research·Andrew T SageShana O Kelley
Dec 26, 2006·Journal of Biochemical and Biophysical Methods·Mariela MartínezEduardo Cortón
Oct 1, 1986·Engineering in Medicine·J C Pickup
Jan 1, 1987·Society for Applied Bacteriology Symposium Series·I J HigginsA P Turner
Feb 20, 2004·Public Health Nutrition·N P SteynA Louheranta
Aug 28, 2020·Microbial Cell Factories·Prem ChandraPankaj Kumar Arora
Nov 1, 1995·Annals of Biomedical Engineering·S YangE Wilkins
Apr 21, 2020·Drug Testing and Analysis·Mahnaz D GholamiEmad L Izake
Oct 1, 1989·Artificial Organs·U FischerE J Freyse

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