PMID: 49051Jun 1, 1975Paper

Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes

Proceedings of the National Academy of Sciences of the United States of America
U Hopfer

Abstract

Isolated, small intestinal microvillous membranes from normal and acutely diabetic rats were compared with respect to D-glucose transport. D-Glucose was accumulated to a greater extent by diabetic membrane vesicles when supplied with energy in the form of a NaC1 or a NaSCN gradient across the vesicle membrane. The difference appeared to be caused by an ability of the diabetic membranes to maintain a higher driving force for active D-glucose transport and not by changes in the glucose "carrier." Increasing the glucose-independent Na-+-conductance of the membrane with monactin or gramicidin D reduced the active accumulation of D-glucose by membrane preparations from both control and diabetic groups. Concentrations of monactin and gramicidin D in the incubation medium of membrane vesicles from diabetic animals could be adjusted so that their D-glucose transport became indistinguishable from that of membranes from normal animals not treated with ionophores. These observatins suggest the microvillous membranes as one site where changes occur in acute diabetes. In addition, the change in the transport properties of the isolated membranes offer a rational explanation for the simultaneous elevation of active intestinal sugar, amino aci...Continue Reading

References

Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jun 1, 1971·The Journal of Clinical Investigation·D V KimbergE Gershon
Apr 1, 1972·The Journal of Clinical Investigation·M FieldW B Greenough
Jun 1, 1973·The Journal of Clinical Investigation·D V KimbergA Henderson
Oct 29, 1974·Biochimica Et Biophysica Acta·H P Schedl, H D Wilson
Jan 5, 1972·Nature: New Biology·E Frömter, J Diamond
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H Murer, U Hopfer
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Oct 22, 1971·Science·G O Barbezat, M I Grossman
Jan 1, 1970·The Journal of Clinical Investigation·W A Olsen, I H Rosenberg
Apr 28, 1961·Biochemical and Biophysical Research Communications·R K CRANE

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Citations

Nov 11, 1982·Pflügers Archiv : European journal of physiology·G GastaldiG Rindi
May 30, 1984·Biochimica Et Biophysica Acta·T Z Csáky, E Fischer
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·P Pothier, J S Hugon
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E Brot-LarocheF Alvarado
Mar 1, 1985·The Journal of Clinical Investigation·A MunnichA Kahn
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Williams, T M Mayhew
Mar 5, 1976·Biochimica Et Biophysica Acta·U HopferR Groseclose
Nov 1, 1983·Metabolism: Clinical and Experimental·G R GourleyW A Olsen
Mar 18, 1991·Biochimica Et Biophysica Acta·Y FujiiS Ishibashi
May 30, 2015·Nutrition Reviews·Danielle M StringerCarla G Taylor
Feb 17, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Eric F PaneChris M Wood
Jan 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Alain VeilleuxEmile Levy
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A IcarteL Accatino
May 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Ruchi SharmaAkhtar Mahmood
Dec 1, 1992·Cell Biochemistry and Function·S al-Sawan, A W Skillen
Aug 24, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell
Jan 1, 1980·CRC Critical Reviews in Biochemistry·J E Lever
Aug 1, 1989·The American Journal of Physiology·M E BlankD F Diedrich
Apr 17, 1997·Biochemical and Biophysical Research Communications·E ChonoS Ishibashi

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