Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis

Journal of Viral Hepatitis
G V PapatheodoridisE K Manesis

Abstract

Diabetes mellitus has been reported to have an increased prevalence and to be associated with more severe fibrosis in patients with chronic hepatitis C. We evaluated the prevalence of diabetes mellitus in patients with chronic hepatitis B or C as well as the possible association between presence of diabetes and extent of liver fibrosis. In total, 434 consecutive patients with histologically documented hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (n = 174) or chronic hepatitis C (n = 260) were studied. The relationships of diabetes and epidemiological, somatomorphic, laboratory and histological patient characteristics were evaluated. Liver histological lesions were blindly evaluated according to the Ishak's classification. Diabetes was present in 58 (13%) patients, without any difference between those with chronic hepatitis B (14%) or C (13%). Diabetes was observed significantly less frequently in patients with fibrosis score 0-2 (7.7%) than 3-4 (10.4%) than 5-6 (29.2%) (P < 0.001). The presence of diabetes was independently associated with higher gamma-glutamyl-transpeptidase (GGT) levels and more severe fibrosis or presence of cirrhosis (P < 0.001) as well as with presence of hepatic steatosis and increased serum...Continue Reading

References

Nov 18, 1967·Lancet·C MegyesiV Marks
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S PetridesG Strohmeyer
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Dec 22, 1998·The American Journal of Gastroenterology·A MangiaA Andriulli
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L F HouriganE E Powell
Aug 14, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I BalikH Yasa
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CaroniaG J Alexander
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Apr 25, 2000·Journal of Clinical Gastroenterology·S H Han, P Martin
Apr 3, 2001·Journal of Hepatology·A D CloustonE E Powell
Apr 12, 2001·Seminars in Liver Disease·Y Falck-YtterA J McCullough
Apr 12, 2001·Seminars in Liver Disease·E M Brunt
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ParadisP Bedossa
May 23, 2002·Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander MontoTeresa L Wright
Oct 3, 2002·The American Journal of Gastroenterology·Vicente OrtizJoaquin Berenguer
Sep 23, 2003·The American Journal of Gastroenterology·Arun J SanyalA Scott Mills
Feb 6, 2004·Gastroenterology·Hashem B El-SeragJames E Everhart
Aug 21, 2004·Journal of Clinical Gastroenterology·Zobair M YounossiRoy Ferguson
Dec 18, 2004·Seminars in Liver Disease·Seela Ramesh, Arun J Sanyal

❮ Previous
Next ❯

Citations

Feb 16, 2008·Internal and Emergency Medicine·Amedeo LonardoNicola Carulli
Sep 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yi-Wen HuangJia-Horng Kao
Jul 28, 2010·Journal of Gastroenterology and Hepatology·Zei-Shung HuangJia-Horng Kao
Jul 28, 2011·Virology Journal·Eman I ElhawaryMohamed Abdel-Hamid
Jan 20, 2009·World Journal of Gastroenterology : WJG·Marcello PersicoRoberto Torella
Apr 25, 2012·World Journal of Gastroenterology : WJG·Cho NaingMala Maung
Jul 6, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ahlam M AhmedAhmed Helmy
Mar 26, 2008·Journal of Endocrinological Investigation·G ForlaniG Marchesini
Jul 29, 2008·Scandinavian Journal of Gastroenterology·Emmanuel A TsochatzisAthanasios J Archimandritis
Apr 7, 2009·Expert Review of Anti-infective Therapy·Amedeo LonardoPaola Loria
Jun 19, 2015·The American Journal of the Medical Sciences·Dalia E DesoukyMohamed S Omar
Jan 21, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jian ZhangGang Qin
Sep 22, 2012·Diabetes Research and Clinical Practice·Michael O IroezinduEkenechukwu E Young
Sep 22, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mandana KhaliliUNKNOWN HBRN
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ibrahim A HanounehNizar N Zein
Sep 26, 2008·Journal of Hepatology·Donna L WhiteHashem B El-Serag
Nov 6, 2007·Clinics in Liver Disease·Ilan S WeisbergSamuel H Sigal
Aug 28, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E TsochatzisA J Archimandritis
Apr 10, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Li-NgE J Bini
Feb 10, 2009·Journal of Viral Hepatitis·A MavrogiannakiA J Archimandritis
Oct 9, 2007·Alimentary Pharmacology & Therapeutics·E TsochatzisA J Archimandritis
Mar 9, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaAntonio Craxì
Dec 17, 2009·Journal of Viral Hepatitis·E TsochatzisA J Archimandritis
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James E Everhart, Elizabeth C Wright
Apr 9, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mauro ViganòMassimo Colombo
Jun 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yi-Wen HuangJia-Horng Kao
Oct 2, 2007·The American Journal of Medicine·Ingrid J Hickman, Graeme A Macdonald
Oct 7, 2015·Frontiers in Endocrinology·Sara Salehi HammerstadYaron Tomer
May 27, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I-Cheng LeeShou-Dong Lee
Sep 14, 2016·Current Diabetes Reports·Rudruidee KarnchanasornKen C Chiu
Dec 9, 2016·Journal of Diabetes Investigation·Jun LuWeiping Jia
Jan 16, 2007·The American Journal of Gastroenterology·Emmanuel TsochatzisAthanasios J Archimandritis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.