Diabetes mellitus is associated with increased acute kidney injury and 1-year mortality after transcatheter aortic valve replacement: A meta-analysis

Clinical Cardiology
George S MinaPaari Dominic

Abstract

Diabetes mellitus (DM) is associated with adverse outcomes after surgical aortic valve replacement. However, there are conflicting data on the impact of DM on outcomes of transcatheter aortic valve replacement (TAVR). DM is associated with poor outcomes after different cardiac procedures. Therefore, DM can also be associated with poor outcomes after TAVR. We searched PubMed and Cochrane Central Register of Controlled Trials for studies that evaluated outcomes after TAVR and stratified at least 1 of the studied endpoints by DM status. The primary endpoint was all-cause mortality at 1 year. Secondary endpoints were early (up to 30 days) mortality, acute kidney injury (AKI), cerebrovascular accident (CVA), major bleeding, and major vascular complications. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random effects models. We included 64 studies with a total of 38 686 patients. DM was associated with significantly higher 1-year mortality (OR: 1.14, 95% CI: 1.04-1.26, P = 0.008) and periprocedural AKI (OR: 1.28, 95% CI: 1.08-1.52, P = 0.004). On the other hand, there were no significant differences between diabetics and nondiabetics in early mortality, CVAs, major bleeding, or major vascular complica...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1994·The Annals of Thoracic Surgery·R P Anderson
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Sean M DonahoeElliott M Antman
May 2, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Masoor KamaleshStephen Sawada
Jul 9, 2010·The Annals of Thoracic Surgery·Michael E HalkosVinod H Thourani
Nov 23, 2010·JACC. Cardiovascular Interventions·Jan-Malte SinningNikos Werner
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Mar 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Samer A M NashefUlf Lockowandt
Mar 27, 2012·The New England Journal of Medicine·Raj R MakkarUNKNOWN PARTNER Trial Investigators
Nov 21, 2012·International Journal of Cardiology·Francesco SaiaAntonio Marzocchi
Nov 12, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marco BarbantiCorrado Tamburino
Apr 1, 2014·The New England Journal of Medicine·David H AdamsUNKNOWN U.S. CoreValve Clinical Investigators
Oct 3, 2015·Cardiovascular Diabetology·Anat BerkovitchPaul Fefer
Nov 28, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Anna SanninoGiovanni Esposito
Feb 10, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yan-Biao LiaoMao Chen
Mar 16, 2016·The American Journal of Cardiology·Mani ArsalanElizabeth M Holper
Mar 27, 2016·The American Journal of Cardiology·Yigal AbramowitzRaj R Makkar
Jul 23, 2016·Journal of the American College of Cardiology·James B HermillerUNKNOWN CoreValve United States Clinical Investigators
Dec 10, 2016·The American Journal of Cardiology·Yinghao SunJian'an Wang

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Citations

Jun 27, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Axel LinkeNorman Mangner
Mar 16, 2021·Journal of Zhejiang University. Science. B·Jiaqi FanJian'an Wang
Apr 29, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Victor RazukGeorge D Dangas
Oct 7, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Shingo MatsumotoUNKNOWN OCEAN-TAVI Investigators

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