Abstract
Chronic hyperglycemia in diabetes mellitus is an oxidative stress created by an imbalance of prooxidants over antioxidant defenses. The pathogenesis would involve several mechanisms including glucose autoxidation, protein glycation, the polyol pathway, and overproduction of superoxide radicals in mitochondria and via NAD(P)H oxidase. Glycemic equilibrium plays a very important role in the prooxidant/antioxidant balance. Macromolecules such as found in the extracellular matrix, lipoproteins, and deoxyribonucleic acid also constitute targets for free radicals in diabetes mellitus. This oxidative tress is involved in the pathophysiology of diabetes complications. The chronic hyperglycemic status also favors glycation reactions (irreversible glucose binding on protein amino groups), thereby leading to advanced glycation endproducts. Via their recognition by cell receptors, advanced glycation endproducts also participate in the development of oxidative stress and the inflammatory status. Involvement of oxidative stress and advanced glycation endproducts in diabetes complications is the basis of the development of adjunct therapies with antioxidant and/or anti)advanced glycation endproducts molecules.
Citations
Oct 31, 2007·Diabetes/metabolism Research and Reviews·Gloria FormosoAgostino Consoli
Jun 16, 2010·Korean Diabetes Journal·Ho Chan Cho
Sep 14, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Takako YokozawaJi Hyun Kim
Feb 2, 2013·Pharmaceutical Biology·Carlos Alberto Yasin WayhsCarmen Regla Vargas
Feb 28, 2018·Archives of Physiology and Biochemistry·Omar SekiouMahfoud Messarah
Sep 15, 2010·Metabolic Brain Disease·Carlos Alberto Yasin WayhsCarmen Regla Vargas
Oct 4, 2018·Phytotherapy Research : PTR·Chan Hum ParkTakako Yokozawa
Sep 25, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jana KostolanskáL'ubomír Barák
Jan 25, 2012·International Journal of Molecular Sciences·Consuelo Lomas-SoriaRosalía Reynoso-Camacho
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·S S LazukoS S Skrinaus
Feb 27, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Karima Bensiameur-TouatiSouhila Aouichat-Bouguerra
Jan 27, 2018·Food & Function·Juanying OuMingfu Wang
Mar 7, 2018·Food & Function·Junqing HuangShiyi Ou
Jan 30, 2021·Journal of Traditional and Complementary Medicine·Omar SekiouMahfoud Messarah
Dec 6, 2018·Ultrasonics Sonochemistry·Arshad MehmoodChengtao Wang
Dec 7, 2018·International Journal of Biological Macromolecules·Pallabi BanerjeeSayani Ray
Oct 3, 2018·Aging and Disease·Maxime FournetAlexis Desmoulière
Sep 8, 2010·Mutation Research·Carlos Alberto Yasin WayhsCarmen Regla Vargas
Oct 18, 2007·Journal of Agricultural and Food Chemistry·Young A LeeTakako Yokozawa
Sep 28, 2021·Frontiers in Endocrinology·Anne-Esther BreytonJulie-Anne Nazare
May 12, 2009·Neuroscience·S Singh KambojR Sandhir
Oct 10, 2021·Angiology·Flora OzkalayciVecih Oduncu
Jun 3, 2018·Gene·A EddaikraN Attal
Jun 1, 2012·Food Chemistry·Renata S FilguerasVéronique Santé-Lhoutellier