Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis

Journal of Gastroenterology and Hepatology
Yusuke KawamuraHiromitsu Kumada

Abstract

The aim of this retrospective study was to examine the relationship between diabetes mellitus and recurrence of hepatocellular carcinoma after potentially curative therapy for hepatocellular carcinoma with nonviral hepatitis. We studied 40 consecutive hepatocellular carcinoma patients who were diagnosed between 1980 and 2006 with hepatocellular carcinoma associated with non-B, non-C hepatitis, and later underwent surgical resection or radiofrequency ablation. Twenty-two out of the 40 patients developed hepatocellular carcinoma recurrence within a median of 3.7 years. In the 18 patients with diabetes mellitus, the cumulative rates of hepatocellular carcinoma recurrence were 22.2% at the first year, 55.6% at the second year, 61.1% at the third year, 61.1% at the fourth year, and 80.6% at the fifth year. The cumulative rates of hepatocellular carcinoma recurrence in 22 nondiabetic patients were 24.6% at the first year, 24.6% at the second year, 31.5% at the third year, 31.5% at the fourth year, and 31.5% at the fifth year. The hepatocellular carcinoma recurrence rate was significantly higher in diabetic patients than in nondiabetics (P = 0.026). The multivariate Cox proportional model identified old age and diabetes as the only si...Continue Reading

References

Oct 1, 1992·Diabetes/metabolism Reviews·L A Bach, M M Rechler
Mar 1, 1992·British Journal of Cancer·V M Macaulay
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C JwoW Y Lui
Jan 1, 1992·Breast Cancer Research and Treatment·D Yee
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShirabeK Sugimachi
Feb 1, 1987·Journal of Hepatology·P J Johnson, R Williams
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriM Ohashi
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TakenakaK Sugimachi
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K IkedaM Kawanishi
Jan 1, 1995·World Journal of Surgery·S KawasakiK Nishimaki
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MiyagawaM Makuuchi
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·C La VecchiaS Franceschi
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IkedaK Sugimachi
Mar 11, 1999·The New England Journal of Medicine·H B El-Serag, A C Mason
Apr 10, 1999·The Orthopedic Clinics of North America·D J Berry
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Sep 14, 1999·The American Journal of Gastroenterology·R T PoonJ Wong
Oct 13, 1999·Seminars in Liver Disease·F X BoschJ Borràs
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Dec 3, 1999·The British Journal of Surgery·C C WuF K P'eng
Dec 10, 1999·Diabetes Care·E S Ford, M E Cogswell
Oct 29, 2000·The American Journal of Gastroenterology·H P CotrimL Lyra
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y KoikeM Omata
Feb 13, 2001·Pathology International·Y ZenY Nakanuma
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal M HassanYehuda Z Patt

❮ Previous
Next ❯

Citations

Jan 18, 2013·World Journal of Gastroenterology : WJG·Hiroshi AbeYoshio Aizawa
Aug 15, 2013·Cancer Letters·Xiao-Yan DuanLiang Qiao
Apr 9, 2010·Acta Diabetologica·Antonio Nicolucci
Aug 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Wei-Min WangJia Fan
Apr 20, 2011·Clinics and Research in Hepatology and Gastroenterology·J HowellA J Nicoll
Mar 16, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuji AraseTetsuro Kobayashi
Mar 26, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuji AraseTetsurou Kobayashi
Mar 18, 2015·Journal of Gastroenterology and Hepatology·Hiroshi AbeYoshio Aizawa
May 13, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masaki KaiboriMasanori Kon
Jan 6, 2016·Journal of Gastroenterology and Hepatology·Kazuto TajiriToshiro Sugiyama
Nov 16, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yunhong TianFeng Shen
Jul 29, 2016·World Journal of Gastroenterology : WJG·Koji FujitaTsutomu Masaki
Mar 23, 2021·Journal of Clinical and Experimental Hepatology·Ameer AbutalebEleanor Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mei-Shu LaiTony Hsiu-Hsi Chen
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Bart J VeldtHarry L A Janssen
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Y IkedaK Sugimachi
Liver International : Official Journal of the International Association for the Study of the Liver
Teh-Ia HuoShou-Dong Lee
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sang Min ParkYoung Ho Yun
© 2022 Meta ULC. All rights reserved