Diabetes: one of few remarkable differences in clinicopathologic features between cirrhotic and noncirrhotic Swedes with hepatocellular carcinoma.

Digestive Diseases and Sciences
J KaczynskiSven Wallerstedt

Abstract

The prognosis of hepatocellular carcinoma (HCC) is usually very poor, so increased knowledge of clinicopathologic characteristics and etiologic factors may improve the clinical handling. Because HCC in many patients is unrecognized before death, it is of particular interest to study cases from a period with a high autopsy frequency. The records and liver biopsies from all patients with a diagnosis of primary liver cancer in Göteborg, Sweden, during a 22-year period were scrutinized. Only patients with evaluable non-neoplastic liver tissue were included in the final analysis. The majority (95%) of 478 HCC cases were autopsied and cirrhosis of the liver could be established in 71%. At presentation, general paramalignant symptoms such as malaise, weight loss, anorexia, and hepatomegaly (84%) were common irrespective of cirrhosis. Alcoholism and diabetes mellitus were each significantly more common among cirrhotics (29% and 20%, respectively; P < .001), than among noncirrhotics, in which cholelithiasis was more common (54%; P < .001). The correlation between diabetes and cirrhosis was independent of reported alcoholism. In an unselected population in a low HCC incidence area, there are few differences in clinicopathologic features ...Continue Reading

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Citations

Oct 2, 2007·The American Journal of Medicine·Ingrid J Hickman, Graeme A Macdonald
Oct 21, 2009·Gastroenterology Research and Practice·Jerzy KaczynskiSven Wallerstedt
Mar 24, 2017·Innovative Surgical Sciences·Stefan Heinrich, Hauke Lang
May 13, 2011·Scandinavian Journal of Gastroenterology·Andreas SchultJerzy Kaczynski
Mar 5, 2021·Zentralblatt für Chirurgie·Lea PenzkoferStefan Heinrich
May 25, 2021·Digestive Diseases and Sciences·Kanokwan PinyopornpanishArthur McCullough

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