Diabetes prevents periodontitis-induced increases in gingival platelet derived growth factor-B and interleukin 1-beta in a rat model

Journal of Periodontology
D L DoxeyA M Iacopino

Abstract

Periodontitis is a chronic inflammatory disease characterized by a progression that is very much dependent on host response. The gingiva can be considered to be in a constant state of wounding (pathologic wounding by bacterial plaque) and a constant state of maintenance/repair. In this context, any metabolic disturbance in the host which compromises tissue repair/wound healing will exacerbate the progression of periodontitis. Diabetes presents an interesting example because two major complications of diabetes are delayed wound healing and periodontitis. Our previous studies indicate that delayed wound healing and periodontitis may be manifestations of a general systemic deficit in diabetes involving alteration of macrophage cytokine gene expression. The present study was designed to determine whether: 1) diabetes-induced metabolic alterations affect gingival cytokine levels; and 2) diabetes-induced metabolic alterations modify the gingival cytokine profile in periodontitis. Sprague-Dawley rats (N=12/group) were injected with streptozotocin (65 mg/kg) into the tail vein to induce diabetes (defined by blood glucose levels > 250 mg/dl) or received the injection vehicle or no treatment as controls. Periodontitis was induced in addi...Continue Reading

References

Jan 1, 1975·Human Pathology·J H LinM S Roginsky
Jan 1, 1992·Progress in Growth Factor Research·P MartinJ McCluskey
Jan 1, 1992·Journal of Clinical Periodontology·B Safkan-Seppälä, J Ainamo
Apr 1, 1991·The Journal of Surgical Research·T J FaheyG T Shires
Feb 1, 1991·Journal of Periodontology·L J EmrichR J Genco
Apr 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·T Tervonen, M Knuuttila
Aug 1, 1986·The Journal of the American Dental Association·D GoteinerC Goteiner
Dec 1, 1985·The Journal of Clinical Investigation·G R GrotendorstA K Harvey
Dec 1, 1970·Journal of Periodontology·K A Hove, R E Stallard
Jul 1, 1967·Journal of Periodontology·R BenvenisteP M Conneally
May 1, 1967·Diabetes·A J Finestone, S R Boorujy
Jan 1, 1983·Journal of Periodontal Research·N S Ramamurthy, L M Golub
Jan 1, 1980·Hospital Practice·M Turck
Mar 1, 1981·Journal of Dental Research·M Manouchehr-PourN F Bissada
Jan 1, 1982·Infection·L Weström
Jan 1, 1980·Infection and Immunity·T E Van DykeR J Genco
Jan 1, 1995·Life Sciences·D L DoxeyA M Iacopino
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C P KiritsyS E Lynch
May 1, 1993·Journal of Clinical Periodontology·H Thorstensson, A Hugoson
Jan 1, 1996·Diabetes·A G NugentG D Johnston

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Citations

Dec 10, 1998·Trends in Microbiology·C A GencoS Amar
May 3, 2013·Journal of Periodontology·John J TaylorEvanthia Lalla
May 3, 2013·Journal of Clinical Periodontology·John J TaylorEvanthia Lalla
Aug 23, 2005·Journal of Biomechanics·Jan G HazenbergDavid Taylor
Aug 8, 2015·Periodontology 2000·Sarah K Sonnenschein, Joerg Meyle
Jan 17, 2008·The Journal of the American Dental Association·Maria Emanuel RyanAngela Kamer
Jun 15, 2016·International Journal of Oral and Maxillofacial Surgery·V MoraschiniG A Peixoto
Mar 13, 2002·Annals of Periodontology·W A Soskolne, A Klinger
Mar 13, 2002·Annals of Periodontology·A M Iacopino
Dec 10, 1999·Journal of Periodontology·C W CutlerA M Iacopino
Mar 4, 2006·Journal of Periodontology·Carla C Pontes AndersenPalle Holmstrup
Jan 13, 2000·Journal of Periodontology·C W CutlerA M Iacopino
Mar 12, 2002·Annals of Periodontology·H F MorrisS Winkler
Apr 25, 2003·Journal of Periodontology·Maria Leticia B PinheiroRicardo A Luz
Jul 26, 2005·Journal of Dental Research·T TomofujiT Watanabe
May 10, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M A Taubman, T Kawai
Feb 24, 2006·Brazilian Oral Research·Ana Cristina Posch MachadoLuiz Fernando Costa Nascimento
Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Jan 10, 2006·Periodontology 2000·P Mark Bartold, A Sampath Narayanan
Jan 12, 2013·The Open Dentistry Journal·Alastair J Sloan, Christopher D Lynch
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Jeffrey O HollingerGary E Friedlaender
May 21, 2003·Periodontology 2000·Thomas W Stanford, Terry D Rees
Nov 25, 2003·Journal of Periodontal Research·Magnús Jón BjörnssonPalle Holmstrup
Oct 16, 2004·World Journal of Gastroenterology : WJG·Li-Ping WuYuan-Qiang Zhang

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