Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis.

Diabetology International
Vasileios P PapadopoulosD. K. Filippou

Abstract

COVID-19 is associated with diabetic ketoacidosis (DKA), hyperglycaemic hyperosmolar state (HHS) and euglycaemic DKA (EDKA); however, evidence regarding parameters affecting outcome and mortality rates is scarce. A systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar from January 2020 to 7 January 2021 to identify all studies describing clinical profile, outcome and mortality rates regarding DKA, HHS, DKA/HHS and EDKA cases in COVID-19 patients. The appropriate Joanna Briggs Institute tools were used for quality assessment; quality of evidence was approached using GRADE. Univariate and multivariate analyses were used to assess correlations between clinical characteristics and outcome based on case reports. Combined mortality rates (CMR) were estimated from data reported in case report series, cross-sectional studies, and meta-analyses. The protocol was submitted to PROSPERO (ID: 229356/230737). From 312 identified publications, 44 were qualitatively and quantitatively analyzed. Critical COVID-19 necessitating ICU (P = 3 × 10-8), DKA/HHS presence (P = 0.021), and AKI (P = 0.037) were independently correlated with death. Increased COVID-19 severity (P = 0.003), elevated lactates (P < 0.001),...Continue Reading

References

Dec 12, 2002·American Journal of Physiology. Cell Physiology·K S LangF Lang
Jul 22, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Samar K BhowmickKenneth R Rettig
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
May 6, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Apr 25, 2014·BMC Research Notes·Trygve Nissen, Rolf Wynn
Apr 17, 2015·BMC Medical Research Methodology·Paul T von Hippel
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Feb 20, 2016·Nature Reviews. Endocrinology·Guillermo Umpierrez, Mary Korytkowski
Mar 10, 2017·International Journal of Molecular Sciences·Heleia Roca-HoMaria Jose Soler
Feb 9, 2018·BMJ Evidence-based Medicine·Mohammad Hassan MuradFateh Bazerbachi
Apr 27, 2020·The Lancet. Diabetes & Endocrinology·Stefan R BornsteinBarbara Ludwig
May 16, 2020·Annales d'endocrinologie·Laura OrioliJean-Cyr Yombi
Jun 4, 2020·Journal of Diabetes Science and Technology·Theocharis KoufakisKalliopi Kotsa
Jun 4, 2020·Advances in Experimental Medicine and Biology·Muhammad Muneer, Ijaz Akbar
Jun 20, 2020·Journal of Diabetes Investigation·Ying Jie CheeEster Yeoh
Jun 27, 2020·Metabolism: Clinical and Experimental·Natalia Chamorro-ParejaPreeti Kishore
Jul 3, 2020·Diabetes Research and Clinical Practice·Nina GoldmanZoe Davies
Jul 6, 2020·The Lancet. Diabetes & Endocrinology·Eleni ArmeniEfthimia Karra
Jul 21, 2020·The Lancet. Diabetes & Endocrinology·Matteo ApicellaStefano Del Prato
Aug 25, 2020·International Journal of Diabetes in Developing Countries·Subhankar Chowdhury, Soumik Goswami
Aug 28, 2020·Diabetes & Metabolic Syndrome·Rimesh PalSukrita Bhattacharjee
Sep 25, 2020·Diabetes & Metabolic Syndrome·Ayman A Al HayekMohamed Al Dawish
Oct 11, 2020·JBI Evidence Synthesis·Zachary MunnEdoardo Aromataris
Oct 24, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tamara Y MilderJerry R Greenfield
Oct 29, 2020·Diabetes & Metabolic Syndrome·Mohammad Shafi KuchaySunil Kumar Mishra
Nov 3, 2020·Frontiers in Endocrinology·Hermine Muniangi-MuhituGuy A Rutter
Nov 25, 2020·Journal of the Chinese Medical Association : JCMA·Ping-Hsing TsaiYi-Ping Yang
Jan 6, 2021·Diabetes & Metabolic Syndrome·Sirisha Kusuma BodduMohammad Shafi Kuchay

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Citations

Aug 3, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Thomas DanneAlexander Seibold

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