PMID: 3384190Jul 1, 1988Paper

Diabetes-related changes in L-tryptophan-induced release of striatal biogenic amines

Diabetes
P A Broderick, J H Jacoby

Abstract

In vivo voltammetry was used to measure the synaptic release of rat striatal dopamine and serotonin after the administration of the amino acid L-tryptophan to streptozocin-induced diabetic rats. Dopamine and serotonin release from rat striatum was studied at a short-term or acute (3-day) interval and a long-term or chronic (3- to 7-wk) interval after the induction of diabetes. The study was also done in age-, sex-, and food-matched controls. The findings show that L-tryptophan decreased dopamine release from rat striatum in nondiabetic rats. The decreased striatal dopamine release, after L-tryptophan administration, was exacerbated in acutely diabetic rats and further exacerbated in chronically diabetic rats. By contrast, rat striatal serotonin release predictably increased after L-tryptophan injection in nondiabetic rats. A further increased striatal serotonin release was seen in acutely diabetic rats. Chronically diabetic rats, however, responded to L-tryptophan with a dramatic and significant decrease in striatal serotonin release. The results show that in acutely diabetic and normal rats, L-tryptophan administration reduced striatal dopamine and increased striatal serotonin release, whereas in chronically diabetic rats, the...Continue Reading

Citations

Sep 1, 1995·Amino Acids·W HeineK D Wutzke
Nov 1, 1991·Brain Research Bulletin·P A Broderick, M F Piercey
Jul 20, 1999·European Journal of Clinical Investigation·R C LittlefordJ J Belch
Jan 1, 1990·Journal of Neurochemistry·Z LackovićM Relja
Nov 5, 1990·Brain Research·J D Schaechter, R J Wurtman

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