Abstract
The importance of adipose tissue in metabolism, as a target for insulin action and a secretor of metabolic regulatory proteins, is increasingly recognized. Lipodystrophic conditions are often associated with significant insulin resistance. The commonest acquired form occurs with highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection. Other medical conditions and drugs also have the potential to cause chronic subcutaneous fat damage. We describe an unfamiliar partial lipodystrophy in a young woman, associated with markedly insulin-resistant diabetes, acquired following allogeneic bone marrow transplantation for childhood leukaemia complicated by late sclerodermatous chronic graft vs. host disease (GVHD). Clinical examination revealed scarring and lipodystrophy affecting mainly legs, thighs, buttocks and forearms but sparing her face, neck and thorax. Her serum adiponectin level was markedly reduced. However, although thiazolidinediones lower insulin resistance and increase subcutaneous peripheral fat in Type 2 diabetes, pioglitazone treatment had little effect on either serum adiponectin, glycaemic control or the lipoatrophy. In this case, effective glycaemic control was best achieved using a com...Continue Reading
References
Jan 1, 1992·Journal of the American Academy of Dermatology·O ChosidowJ Revuz
Feb 2, 2000·Nature Genetics·S ShackletonR C Trembath
Oct 21, 2000·Lancet·M TaskinenM Lipsanen-Nyman
Aug 2, 2001·Nature Medicine·T YamauchiT Kadowaki
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·P AminS R Page
Apr 9, 2002·Lancet·Jean Philippe BastardJacqueline Capeau
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Dali ChenAbhimanyu Garg
Sep 27, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·Katharine R OwenAndrew T Hattersley
Feb 14, 2004·Lancet·Andrew CarrUNKNOWN Rosey investigators
Mar 19, 2004·The New England Journal of Medicine·Abhimanyu Garg
May 15, 2004·British Journal of Haematology·Meghan A Higman, Georgia B Vogelsang
Citations
Jan 1, 2010·Clinical, Cosmetic and Investigational Dermatology·Seyed Reza Mousavi
Dec 17, 2014·Orphanet Journal of Rare Diseases·Marie-Christine VantyghemUNKNOWN Société Française de Thérapie Cellulaire
Jul 7, 2009·Biomaterials·Biman B Mandal, Subhas C Kundu
Sep 4, 2007·Biomaterials·Joshua R MauneyDavid L Kaplan
Sep 3, 2011·Pediatric Transplantation·Sarantis LivadasCatherine Dacou-Voutetakis
May 23, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·R RajendranC D Byrne
Apr 4, 2017·Pediatric Blood & Cancer·Leslie KimuraKuk-Wha Lee
Sep 3, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Alissa R SegalJeffrey A Jackson
May 11, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mayumi HosokawaTomonobu Hasegawa
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sarah E MaysonMichael R Rickels
May 6, 2020·Expert Review of Endocrinology & Metabolism·Maria C Foss-FreitasElif A Oral
Jul 20, 2017·Journal of Endocrinological Investigation·G CeccariniF Santini
Dec 14, 2018·Journal of Medical Case Reports·Yusuke ShibataJun Wada
May 11, 2020·Journal of Cancer Survivorship : Research and Practice·Ava LorencUNKNOWN CTYA HSCT Adipose and Muscle Late Effects Working Group
Feb 13, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Wendy S LaneJay S Skyler
May 2, 2017·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Masanori AdachiHiroaki Goto
Aug 14, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea Z PereiraMary E Flowers
Dec 29, 2020·Physiological Reviews·Koini LimDavid B Savage
Jun 21, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Jay GilbertOwen G Jones
May 1, 2021·Journal of Clinical Medicine·Daniel TewsMartin Wabitsch
Nov 25, 2020·Endocrine Journal·Masanori AdachiYumi Asakura
Aug 11, 2021·Endocrine Journal·Tomohiro TanakaKazuwa Nakao
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity