Diabetic animal models

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
K Buschard

Abstract

Insulin-dependent (type 1) diabetes is a frequent disease with an incidence of up to about 1%. It requires daily treatment and serious late complications are observed. Good animal models exist for studying diabetes. These can be categorized as animals with spontaneously developing diabetes (BB rats, NOD mice) and as animals with induced diabetes (e.g. by virus). Immunodeficient nude mice have also been widely used. None of the models is perfect, but each has contributed to our present knowledge of the disease. Studies on the pathogenesis of type 1 diabetes are given as an example. Recently, experience with prophylactic treatment of animals in order to prevent diabetes has been applied to humans with promising results.

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Citations

Aug 3, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heike WeissDirk Wedekind
May 20, 1998·Research in Immunology·M G von Herrath
Aug 18, 2012·International Journal of Dentistry·M T PöllänenV-J Uitto
Feb 3, 2012·Microscopy Research and Technique·Hugo Tadeu MetidieriEduardo José Caldeira
Jun 3, 2011·APMIS. Supplementum·Karsten Buschard
Oct 12, 2005·Current Opinion in Immunology·Margo Honeyman
Jun 21, 2002·Microvascular Research·J E SandersS Lamont

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