Diabetic cardiac autonomic neuropathy: Do we have any treatment perspectives?

World Journal of Diabetes
Victoria A Serhiyenko, Alexandr A Serhiyenko

Abstract

Cardiac autonomic neuropathy (CAN) is a serious and common complication of diabetes mellitus (DM). Despite its relationship to an increased risk of cardiovascular mortality and its association with multiple symptoms and impairments, the significance of CAN has not been fully appreciated. CAN among DM patients is characterized review the latest evidence and own data regarding the treatment and the treatment perspectives for diabetic CAN. Lifestyle modification, intensive glycemic control might prevent development or progression of CAN. Pathogenetic treatment of CAN includes: balanced diet and physical activity; optimization of glycemic control; treatment of dyslipoproteinemia; correction of metabolic abnormalities in myocardium; prevention and treatment of thrombosis; use of aldose reductase inhibitors; dihomo-γ-linolenic acid (DGLA), acetyl-L-carnitine, antioxidants, first of all α-lipoic acid (α-LA), use of long-chain ω-3 and ω-6 polyunsaturated fatty acids (ω-3 and ω-6 PUFAs), vasodilators, fat-soluble vitamin B1, aminoguanidine; substitutive therapy of growth factors, in severe cases-treatment of orthostatic hypotension. The promising methods include research and use of tools that increase blood flow through the vasa vasorum...Continue Reading

Citations

Sep 26, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Scott M WilliamsJohn P H Wilding
Jan 24, 2018·World Journal of Diabetes·Victoria A Serhiyenko, Alexandr A Serhiyenko
Oct 2, 2019·Experimental and Therapeutic Medicine·Fernando MagdalenoAna Rosa Rincón-Sánchez
Jan 26, 2021·Clinical Neurophysiology Practice·Ismail Ibrahim HusseinMarwan S M Al-Nimer

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