Diabetic Cardiomiopathy Progression is Triggered by miR122-5p and Involves Extracellular Matrix: A 5-Year Prospective Study.

JACC. Cardiovascular Imaging
Riccardo PofiAndrea M Isidori

Abstract

The purpose of this study was to follow the long-term progression of diabetic cardiomyopathy by combining cardiac magnetic resonance (CMR) and molecular analysis. The evolution of diabetic cardiomyopathy to heart failure affects patients'morbidity and mortality. CMR is the gold standard to assess cardiac remodeling, but there is a lack of markers linked to the mechanism of diabetic cardiomyopathy progression. Five-year longitudinal study on patients with type 2 diabetes mellitus (T2DM) enrolled in the CECSID (Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes) trial compared with nondiabetic age-matched controls. CMR with tagging together with metabolic and molecular assessments were performed at baseline and 5-year follow-up. A total of 79 men (age 64 ± 8 years) enrolled, comprising 59 men with T2DM compared with 20 nondiabetic age-matched controls. Longitudinal CMR with tagging showed an increase in ventricular mass (ΔLVMi = 13.47 ± 29.66 g/m2; p = 0.014) and a borderline increase in end-diastolic volume (ΔEDVi = 5.16 ± 14.71 ml/m2; p = 0.056) in men with T2DM. Cardiac strain worsened (Δσ = 1.52 ± 3.85%; p = 0.033) whereas torsion was unchanged (Δθ = 0.24 ± 4.04°; p = 0.737), revealing a loss of the adap...Continue Reading

Associated Clinical Trials

References

Jul 1, 1974·The American Journal of Cardiology·W B KannelW P Castelli
Jun 14, 2002·Cardiovascular Research·John C Chatham, Anne-Marie L Seymour
Nov 13, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jan D'hoogeJadranka Separovic
Nov 23, 2006·Journal of the American College of Cardiology·Partho P SenguptaBijoy K Khandheria
Mar 19, 2008·Basic Research in Cardiology·Sophie Van LinthoutCarsten Tschöpe
Jan 12, 2010·Circulation. Cardiovascular Imaging·Michel G KhouriMark H Drazner
Jul 20, 2010·Amino Acids·T Klein, R Bischoff
Mar 23, 2011·Herz·B MaischS Pankuweit
Jun 1, 2011·Heart Failure Reviews·Inês Falcão-Pires, Adelino F Leite-Moreira
Sep 1, 2012·Circulation. Heart Failure·Shannon M DunlayMargaret M Redfield
May 1, 2013·Nature Reviews. Endocrinology·Claudiane Guay, Romano Regazzi
Oct 30, 2013·International Wound Journal·Bruno AmatoStefano de Franciscis
Apr 19, 2015·European Heart Journal·Petar M Seferović, Walter J Paulus
Dec 9, 2015·Circulation·Judith G RegensteinerUNKNOWN American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health, Council on Epidemiolog
Dec 19, 2015·Nature Reviews. Endocrinology·Guanghong JiaJames R Sowers
Sep 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Nuno Cortez-DiasFrancisco J Enguita
Mar 6, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Anita RegmiLuLu Chen
Mar 13, 2019·International Journal of Molecular Sciences·Jovana Nikolajević StarčevićMišo Šabovič
May 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Mary Anna VenneriAndrea M Isidori
Jul 22, 2019·Cells·Robin M W Colpaert, Martina Calore
Sep 11, 2019·European Heart Journal·Juhani KnuutiUNKNOWN ESC Scientific Document Group
Nov 24, 2019·International Journal of Cardiology·Stefan StojkovicAlexander Niessner

❮ Previous
Next ❯

Citations

Jan 15, 2021·Heart Failure Reviews·Alieh GholaminejadShaghayegh Haghjooy Javanmard
Mar 11, 2021·JACC. Basic to Translational Science·Haobo Li, Anthony Rosenzweig
Mar 22, 2021·JACC. Cardiovascular Imaging·Geneviève A Derumeaux, Thomas d'Humières

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.