Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options

The American Journal of Medicine
Ashish AnejaMichael E Farkouh

Abstract

Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of coronary artery disease and hypertension. Hyperglycemia seems to be central to the pathogenesis of diabetic cardiomyopathy and to trigger a series of maladaptive stimuli that result in myocardial fibrosis and collagen deposition. These processes are thought to be responsible for altered myocardial relaxation characteristics and manifest as diastolic dysfunction on imaging. Sophisticated imaging technologies also have permitted the detection of subtle systolic dysfunction in the diabetic myocardium. In the early stages, these changes appear reversible with tight metabolic control, but as the pathologic processes become organized, the changes are irreversible and contribute to an excess risk of heart failure among diabetic patients independently of common comorbidities, such as coronary artery disease and hypertension. Therapeutic agents specifically targeting processes that lead to these pathophysiologic changes are in the early stages of development. Although glycemic control and early administration of neurohormonal antagonists remain the cornerstones of therapeutic approaches, newer treatment targets are currently being explored.

References

May 1, 1991·The Journal of Clinical Investigation·B TesfamariamR A Cohen
Dec 1, 1990·Annals of Medicine·M I UusitupaK E Airaksinen
Aug 1, 1989·The American Journal of Medicine·A BouchardN B Schiller
Feb 19, 1988·Diabetes Research and Clinical Practice·J R AttaliJ Sebaoun
Jul 1, 1988·Journal of the American College of Cardiology·S W ZarichR W Nesto
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Jul 1, 1974·The American Journal of Cardiology·W B KannelW P Castelli
Dec 1, 1984·Human Pathology·V W FischerL S Larose
Jan 1, 1984·Acta Medica Scandinavica·J AiraksinenJ Takkunen
Jan 1, 1993·Journal of Clinical Pathology·M ShimizuI Nakanishi
Nov 1, 1995·Journal of Biochemistry·K N IslamN Uozumi
Apr 1, 1997·Cardiovascular Research·A Malhotra, V Sanghi
Mar 17, 2000·Free Radical Biology & Medicine·M Qian, J W Eaton
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·J D BisognanoD J Port
May 12, 2000·Journal of the American College of Cardiology·J S GottdienerR C Boineau
Sep 1, 2000·Journal of Molecular and Cellular Cardiology·S ChenS Chakrabarti
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Takehisa AbeMiyako Takaki
Feb 25, 2003·Journal of the American College of Cardiology·Zhi You FangThomas H Marwick
Nov 19, 2003·Archives of Biochemistry and Biophysics·Mariana D Argirova, Beryl J Ortwerth

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Citations

Mar 23, 2011·Herz·B MaischS Pankuweit
Mar 29, 2012·Heart Failure Reviews·Takayuki MikiTetsuji Miura
Sep 30, 2010·Molecular and Cellular Biochemistry·Mengxiong TangMing Zhong
Feb 25, 2010·Reviews in Endocrine & Metabolic Disorders·Sihem Boudina, Evan Dale Abel
Apr 25, 2012·Current Diabetes Reports·Maggie N Tillquist, Thomas M Maddox
Aug 6, 2013·Pathology, Research and Practice·Edson SilvaIzabel R S C Maldonado
Jan 10, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Brittany LawEdie C Goldsmith
Aug 8, 2012·Cardiovascular Research·Ilana Talior-VolodarskyChristopher A McCulloch
Oct 28, 2011·American Journal of Physiology. Cell Physiology·Rita M MaaloufHanna E Abboud
Jul 31, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Baojun DongF Susan Wong
Aug 5, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lakshmi PulakatJames R Sowers
Jul 13, 2011·Experimental Diabetes Research·Christina VoulgariChristodoulos Stefanadis
Oct 7, 2011·Experimental Diabetes Research·Lakshmi PulakatJames R Sowers
Apr 27, 2011·Cardiovascular Diabetology·Célia M C StrunzMonica V Marquezini
May 17, 2012·PloS One·Abdul Q SheikhDaria A Narmoneva
Nov 9, 2010·Vascular Health and Risk Management·Christina VoulgariNicholas Tentolouris
Nov 10, 2012·Diabetes Care·Ralph L WidyaHildo J Lamb
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Paras Kumar MishraSuresh C Tyagi
Aug 1, 2013·International Journal of Molecular Sciences·Olaf BrouwersCasper G Schalkwijk
Feb 28, 2013·Heart Failure Reviews·Michael IsfortLoren E Wold
Mar 5, 2013·Heart Failure Reviews·Adriana Adameova, Naranjan S Dhalla
Feb 5, 2014·Current Atherosclerosis Reports·K LevittK A Connelly
Nov 6, 2012·Heart Failure Reviews·Ana Maria SeguraL Maximilian Buja
Oct 12, 2012·The International Journal of Cardiovascular Imaging·Cornelis J RoosArthur J Scholte
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Madhu KhullarPawan K Singal
Nov 29, 2012·Herz·M NiemannF Weidemann
Dec 12, 2012·Herz·P M SeferovićB Maisch
Mar 4, 2010·Acta Diabetologica·Roberto TarquiniGian Franco Gensini

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