Diabetic cataract and the total antioxidant status in aqueous humor

Clinical Chemistry and Laboratory Medicine : CCLM
H AksoyF Akçay

Abstract

Some mechanisms have been proposed for cataract formation in diabetes mellitus such as excessive tissue sorbitol concentrations, abnormal glycosylation of lens proteins and increased free radical production in the intraocular region. We measured total antioxidant status and uric acid levels in aqueous humor from diabetic (n=20) and non-diabetic subjects (n=16) with cataracts. The patients with diabetes and cataract had significantly lower aqueous humor total antioxidant status than those with senile cataract (p = 0.001). Serum and aqueous humor uric acid levels were significantly lower in the diabetic cataract group compared to the senile cataract group. In the diabetic cataract group, the aqueous humor antioxidant status correlated positively with the aqueous humor uric acid levels (p < 0.05). The results of this study suggest that reduced aqueous humor antioxidant status might be associated with reduced aqueous humor uric acid in patients with diabetic cataract. This decrease in aqueous humor uric acid levels might lead to the acceleration of cataract formation.

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Citations

Nov 5, 2008·Biological Trace Element Research·Zuhal YildirimNedret Kilic
Dec 19, 2012·Human Genomics·Konstantinos Sousounis, Panagiotis A Tsonis
Apr 23, 2009·Indian Journal of Ophthalmology·S K GuptaRohit Saxena
Oct 19, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·P P-C ChiangT Y Wong
Jun 13, 2008·Acta Ophthalmologica·Jutta Horwath-WinterOtto Schmut

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