Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1, and endothelial dysfunction in streptozotocin treated rats

Diabetes/metabolism Research and Reviews
Yousif A ShamsaldeenLisa A Lione

Abstract

Diabetes is a complex progressive disease characterized by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidized LDL (Ox-LDL) is elevated in diabetes and may contribute to endothelial dysfunction. The aim of this study was to relate the serum levels of Ox-LDL with endothelial dysfunction in streptozotocin (STZ)-diabetic rats and to further explore the changes in endothelial nitric oxide synthase (eNOS) and caveolin-1 (CAV-1) expression in primary aortic endothelial cells. Diabetes was induced with a single intraperitoneal injection of STZ in male Wistar rats. During the hyperglycaemic diabetes state serum lipid markers, aortic relaxation and aortic endothelial cell eNOS and CAV-1 protein expressions were measured. Elevated serum Ox-LDL (STZ 1486 ± 78.1 pg/mL vs control 732.6 ± 160.6 pg/mL, P < .05) was associated with hyperglycaemia (STZ 29 ± 0.9 mmol/L vs control: 7.2 ± 0.2 mmol/L, P < .001) and hypertriglyceridaemia (STZ 9.0 ± 1.5 mmol/L vs control: 3.0 ± 0.3 mmol/L, P < .01) in diabetic rats. A significant reduction was observed in STZ-diabetic aortic endothelial cell eNOS and CAV-1 of 40% and 30%, respectively, accompanied by a compromised STZ-diabetic carbachol-induced vasodilation (STZ...Continue Reading

References

Jun 1, 1992·Diabetes Research and Clinical Practice·Y HaranoY Taniguchi
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R J DeckelbaumS Eisenberg
Mar 15, 1996·The Journal of Biological Chemistry·P W ShaulT Michel
Apr 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Philippe G FrankMichael P Lisanti
Jun 26, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P G SchefferT Teerlink
Oct 29, 2005·Circulation Research·Xiaoqiang Yao, Christopher J Garland
Dec 15, 2005·Heart, Lung & Circulation·Michael WeiLindsay Brown
Nov 6, 2009·Antioxidants & Redox Signaling·Irena LevitanPapasani V Subbaiah
Dec 8, 2010·British Journal of Pharmacology·Christopher J GarlandKim A Dora
Jan 4, 2012·Diabetes Care·UNKNOWN American Diabetes Association
Dec 3, 2014·Redox Biology·Atif Ur RehmanLouise S Mackenzie
Sep 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Venkatesan AmalanArumugam Ramakrishnan

❮ Previous
Next ❯

Citations

Aug 3, 2019·International Journal of Molecular Sciences·Kenichi Goto, Takanari Kitazono
Jul 19, 2019·Mediators of Inflammation·Zhimei WangJunjie Zhang
May 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrick Kwabena OduroQilong Wang
Mar 30, 2019·Biochemical and Biophysical Research Communications·Yousif A ShamsaldeenNeil V Marrion
Nov 6, 2018·European Journal of Pharmacology·Yousif A ShamsaldeenChristopher D Benham
Aug 19, 2020·European Journal of Pharmacology·Yousif A ShamsaldeenChristopher D Benham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.