Diabetic fatty liver disease is associated with specific changes in blood-borne markers

Diabetes/metabolism Research and Reviews
S SharmaS M MacRury

Abstract

Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those without. A total of 68 participants were recruited from diabetes and liver clinics. Fatty liver disease was indicated by routine blood tests and ultrasonography. Forty-seven participants had type 2 diabetes; of them, 18 had no fatty liver disease as defined previously (DNoFLD) and 29 had fatty liver disease (DFLD); the remaining 21 had fatty liver disease but no diabetes (NonDFLD). Serum samples were analyzed for adiponectin (APN), alanine and aspartate aminotransferases and plasma for cholesterol, triglyceride, hyaluronic acid (HA), procollagen peptide III, alkaline phosphatase and fibrinogen. Hyaluronic acid and procollagen peptide III were significantly higher and adiponectin significantly lower in DFLD than NonDFLD and DNoFLD, the difference being particularly marked for hyaluronic acid and APN. There was no difference in these markers between NonDFLD and DNoFLD and no association between any plasma or serum marker and ultraso...Continue Reading

References

Mar 15, 2001·European Journal of Gastroenterology & Hepatology·E GianniniR Testa
Oct 5, 2001·Seminars in Liver Disease·D SchuppanE G Hahn
Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiArthur J McCullough
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Mar 15, 2005·European Journal of Endocrinology·Claudio PaganoRoberto Vettor
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·M TrombettaM Muggeo
Aug 19, 2006·Journal of Clinical Gastroenterology·Matthew W Pantsari, Stephen A Harrison
Sep 13, 2006·Endocrine Journal·Shinichiro MineYoshiya Tanaka
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
May 18, 2007·Annual Review of Cell and Developmental Biology·Dianhua JiangPaul W Noble
Oct 2, 2007·The American Journal of Medicine·Ingrid J Hickman, Graeme A Macdonald
Nov 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Indra Neil GuhaWilliam M Rosenberg
Apr 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Nathalie C LeiteClaudia R L Cardoso
Jun 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sophie JacqueminetThierry Poynard
Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna Ludovica FracanzaniSilvia Fargion
Sep 9, 2008·European Heart Journal·Gideon R HajerFrank L J Visseren
Feb 7, 2009·Diabetes & Metabolism·L Castera
Feb 27, 2009·Clinical Science·Christopher D ByrneMohamed H Ahmed
Jun 9, 2009·Journal of Hepatology·Curtis K ArgoStephen H Caldwell
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Noreen HossainZobair Younossi
Oct 13, 2009·Clinics in Liver Disease·Curtis K Argo, Stephen H Caldwell
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G MussoM Cassader

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Indra Neil GuhaWilliam M Rosenberg
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Scott C Leverage, Paul Angulo
© 2021 Meta ULC. All rights reserved