Diabetic keto-acidosis as a presentation of cystic fibrosis-related diabetes: a case report

Journal of Diabetes and Its Complications
Vera EenkhoornChristophe De Block

Abstract

Cystic fibrosis (CF) is one of the most common genetically inherited diseases and often complicated by diabetes mellitus. With increasing longevity, the incidence and prevalence of cystic fibrosis-related diabetes (CFRD) rise and microvascular complications develop. CFRD is an entity on its own with characteristics seen in both type 1 and type 2 diabetes. Keto-acidosis, a potentially life-threatening complication of diabetes, is an extremely rare presentation of CFRD. Here we present the history of a 21-year-old CF patient with no prior diagnosis of CFRD who developed keto-acidosis after an episode of pulmonary infection. Based on this case report we would like to emphasize the importance of screening for and early treatment of CFRD. We also discuss the management policy of CFRD and when and whether to initiate insulin therapy.

References

Jun 6, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A D R MackieF P Edenborough
Feb 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Amanda L BrennanEmma H Baker
Sep 6, 2005·Diabetes & Metabolism·M CostaR Rabasa-Lhoret
Oct 5, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Laura MinicucciRenata Lorini
Feb 27, 2007·Diabetes Care·Sarah Jane SchwarzenbergAntoinette Moran
May 27, 2008·Pediatric Pulmonology·Kamlesh MohanMartin J Walshaw
Aug 10, 2010·Core Evidence·Angelo L Gaffo, Kenneth G Saag

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Citations

Jun 12, 2014·Current Diabetes Reports·Donal O'Shea, Jean O'Connell
Oct 19, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Gregory C Jones, Christopher A R Sainsbury

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