Diabetic ketoacidosis among pregnant and non-pregnant women: a comparison of morbidity and mortality

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Michelle RougerieHaim A Abenhaim

Abstract

Diabetic ketoacidosis (DKA) is a critical diagnosis that can cause severe morbidity and mortality in the diabetic population. Although it is rare in pregnancy, the aim of this study is to compare DKA in pregnant women with age-matched non-pregnant women to determine if outcomes are influenced by pregnancy. A population-based age-matched retrospective cohort was carried out using data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1999 to 2013. Pregnant patients with DKA were age-matched with non-pregnant controls also admitted with DKA at a ratio of 1:10. Severe morbidities and mortality were compared among the two groups. Logistic regression was used to adjust for baseline characteristics and comorbidities. We identified 4661 cases of DKA in pregnancy during our study period, which were age-matched to 46,610 non-pregnant controls. Pregnant women with DKA were more likely to stay in hospital for >3 d (odds ratios (OR) 2.15, 95% CI 2.06-2.25) and had more associated renal failure (OR 2.86, 95% CI 1.76-4.55); however, they were less likely to require ventilation (OR 0.70, 95% CI 0.62-0.79), experience systemic inflammatory response syndrome (OR 0.53, 95% CI 0.38-0.73), or seizures (OR 0.49, 95% ...Continue Reading

References

Jan 1, 1993·American Journal of Perinatology·M N MontoroS H Golde
Oct 1, 1996·American Journal of Perinatology·M T CullenE Sivan
Sep 18, 2002·The Milbank Quarterly·John Z Ayanian, Joel S Weissman
Oct 9, 2007·Obstetrics and Gynecology Clinics of North America·Jason A Parker, Deborah L Conway
Apr 7, 2010·Diabetes Research and Clinical Practice·Guanmin ChenHude Quan
Apr 3, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sudha DarbhamullaPaul Bosio
Aug 14, 2012·Paediatric and Perinatal Epidemiology·Sarah L GoffPeter K Lindenauer
Aug 7, 2013·Seminars in Perinatology·Margarita de Veciana
Nov 5, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Shilpaja J KarpateChandresh Patel
Jan 15, 2014·Current Diabetes Reports·Etoi A Garrison, Shubhada Jagasia
Jan 28, 2014·Obstetrics and Gynecology·Baha M Sibai, Oscar A Viteri
Apr 7, 2016·Saudi Journal of Anaesthesia·Gómez-Ríos MáDiéguez-Fernández M
Apr 22, 2016·Current Diabetes Reviews·Anar ModiFarah Morgan
Jul 9, 2016·Anesthesia and Analgesia·Matthew J G SigakisBrian T Bateman
Jun 14, 2017·Diabetes Care·Fritha J R MorrisonAlexander Turchin

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