Diabetic ketoacidosis complicated by generalized venous thrombosis: a case report and review

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Sujith V CherianVincent Frechette

Abstract

Venous thromboembolism is a rarely described complication of diabetic ketoacidosis (DKA). We describe a 21-year-old male patient with poorly controlled type 1 diabetes mellitus who was admitted with DKA, presumably secondary to noncompliance, whose clinical picture was complicated by generalized thrombosis involving multiple venous locations including renal vein, pulmonary vasculature, external iliac and common iliac veins. The patient had no family history of any coagulation disorders and a hypercoagulabilty work-up remained negative. The patient was subsequently anticoagulated with heparin and discharged home on warfarin. To the best of our knowledge, this is the first reported case of multiple venous thromboses occurring as a complication of DKA with no other risk factors. We also reiterate that although rare, venous thrombosis should always be considered as a potential complication of DKA.

References

Apr 1, 2003·Endocrine Research·G F CarlMary H Jonah
Dec 24, 2005·Journal of Vascular and Interventional Radiology : JVIR·Stan ZipserYoung S Kang
Jan 18, 2006·Diabetes Research and Clinical Practice·G V GillP English

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Citations

Apr 8, 2014·World Journal of Gastroenterology : WJG·Giovanni MaconiRoberto de Franchis
Jul 6, 2018·Case Reports in Critical Care·Hannah KinoshitaPrashant J Purohit
May 16, 2020·Nature Reviews. Disease Primers·Ketan K DhatariyaGuillermo E Umpierrez

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