PMID: 6540713Jan 1, 1984Paper

Diabetic myocardial alterations in ultrastructure and function

Experimental Pathology
Mária Zsófia KoltaiGábor Pogátsa

Abstract

Myocardial samples taken from six healthy and six alloxan-diabetic dogs by means of percutaneous needle-biopsy were investigated electronmicroscopically. Specific increase in the number of collagen fibers and that of mitochondria were demonstrated beside the widening of Z bands. In the same experimental animals, a close, inverse correlation was detected (y = 0.0068x + 0.1680; r = 0.8648; F = 29.6705; n = 12) between the values of the left ventricular passive elastic modulus and those of the plasma glucose disappearance rate determined immediately before the haemodynamic investigation. On the basis of the ultrastructural findings, the proliferation of collagen fibers can be made also responsible for functional disorder of the diabetic myocardium.

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Citations

Oct 1, 1989·Acta diabetologica latina·K W SmallD L Hatchell
Jul 1, 1996·Diabetes Research and Clinical Practice·N TribulováJ Slezák
Jul 1, 2008·Biophysical Journal·Jeffrey G JacotJeffrey H Omens
May 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Giacinta GuariniIan N Bratz
May 21, 2019·Biomimetics·María Luisa Durán-PasténMathieu Hautefeuille
Jan 1, 1986·Basic Research in Cardiology·M Z KoltaiG Pogátsa
Apr 15, 2009·Clinical Science·Omar AsgharRayaz A Malik

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