Diabetic nephropathy and quality of life among youths with long-duration type 1 diabetes: A population-based cross-sectional study

Pediatric Diabetes
Thaddäus TönniesJoachim Rosenbauer

Abstract

To investigate whether diabetic nephropathy (DN) is associated with lower quality of life (QOL) in youths with long-duration type 1 diabetes and whether associations differ by diabetes duration. Overall, 1,462 youths aged 11 to 17 years with diabetes onset between 0 and 4 years of age and at least 10 years diabetes duration completed questionnaires on QOL between 2009 and 2016. Chronic generic and diabetes-specific QOL (diabetes impact and treatment scale) were assessed with three scales of the DISABKIDS instruments. Information on DN was obtained from the diabetes patient follow-up registry ("Diabetes-Patienten-Verlaufsdokumentation") with DN defined as micro- or macroalbuminuria. Linear regression analyses were used to evaluate the association between QOL and DN. To adjust for potential confounders, we applied inverse probability of treatment weighting for the linear regression. In adjusted analysis, DN was associated with lower QOL in the chronic generic and the two diabetes-specific DISABKIDS scales. Overall, the observed effects were not clinically relevant but increased consistently with longer diabetes duration. Among those with at least 16 years diabetes duration, differences in QOL between patients with vs without DN w...Continue Reading

References

May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
Nov 24, 1998·European Child & Adolescent Psychiatry·R GoodmanV Bailey
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·R GoodmanH Meltzer
Jul 13, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J HahlO Simell
Dec 24, 2004·Diabetes Care·Janet SilversteinUNKNOWN American Diabetes Association
Apr 4, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Marie-Claude SimeoniUNKNOWN DISABKIDS Group
Jul 9, 2008·Archives of Pediatrics & Adolescent Medicine·Michelle J NaughtonUNKNOWN SEARCH for Diabetes in Youth Study Group
Nov 4, 2008·Acta Paediatrica·J E ChaplinB Lindblad
Feb 12, 2009·Pediatric Diabetes·Lena HanbergerSam Nordfeldt
Jul 29, 2009·Archives of Internal Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research GroupTrevor J Orchard
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aila J AholaUNKNOWN FinnDiane Study Group
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jul 14, 2010·Pediatric Diabetes·K Otfried SchwabUNKNOWN DPV Science Initiative and the Competence Network Diabetes mellitus
Jun 20, 2012·Health and Quality of Life Outcomes·Agneta A PagelsSusanne Heiwe
Jan 22, 2014·Pediatric Diabetes·Yoon Hi ChoKim C Donaghue
Jul 7, 2016·Journal of Diabetes Science and Technology·Sabine E HoferUNKNOWN Austrian/German DPV Initiative
Dec 10, 2017·Diabetes Care·UNKNOWN American Diabetes Association
Dec 22, 2017·Diabetes Care·Jaakko HelvePatrik Finne
Jan 23, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·P PrahaladD M Maahs

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.