Diabetic nephropathy: Is there a role for oxidative stress?

Free Radical Biology & Medicine
Manpreet K Sagoo, Luigi Gnudi

Abstract

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy. Studies in experimental animal models of diabetes strongly implicate oxidant species as a major determinant in the pathophysiology of diabetic kidney disease. The translation, in the clinical setting, of these concepts have been quite disappointing, and new theories have challenged the concepts that oxidative stress per se plays a role in the pathophysiology of diabetic kidney disease. The concept of mitochondrial hormesis has been introduced to explain this apparent disconnect. Hormesis is intended as any cellular process that exhibits a biphasic response to exposure to increasing amounts of a substance or condition: specifically, in diabetic kidney disease, oxidant species may represent, at determined concentration, an essential and potentially protective factor. It could be postulated that excessive production or inhibition of oxidant species formation might result in an adverse phenotype. This review discusses the evidence underlying these two apparent contradicting concepts, with the aim to propose and speculate on potential mechanisms underlying the role of oxidant species in the pathophysiology of diabetic nephropathy and possibly open f...Continue Reading

Citations

Jul 28, 2018·European Journal of Clinical Investigation·Juan Li, Xingping Shen
Aug 30, 2018·Acta Diabetologica·Silvia Maestroni, Gianpaolo Zerbini
Jun 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi-Jin ZhuYong-Gui Wu
Dec 6, 2019·Chembiochem : a European Journal of Chemical Biology·Lisa J AlcockJustin M Chalker
May 31, 2020·International Journal of Molecular Sciences·Sandra Rayego-MateosJesús Egido
May 23, 2020·Scientific Reports·Monica LocatelliPaola Cassis
May 17, 2018·Frontiers in Pharmacology·Litao BaiJunping Wei
Aug 1, 2019·International Journal of Molecular Sciences·Anila DuniEvangelia Dounousi
Sep 12, 2019·Journal of the American Society of Nephrology : JASN·Glenn M ChertowUNKNOWN GS-US-223-1015 Investigators
Jun 23, 2020·Oxidative Medicine and Cellular Longevity·Xiaoyu ZhouZhonggui He
Jun 23, 2020·Journal of Immunology Research·Yongwang YanHongqi Yang
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Jing GuoWei Jing Liu
Jun 11, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yanhong QiaoHuimin Niu
Jul 3, 2018·Frontiers in Medicine·Adriana Torres CrignaKaren Bieback
Jul 14, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Thomas IttoopSethu Reddy
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yan YangHeqing Huang
Feb 14, 2021·International Journal of Biological Macromolecules·Yuanpei LianLiang Feng
Nov 17, 2020·American Journal of Physiology. Renal Physiology·Kerstin UnterschemmannManuel Grundmann
Jan 29, 2021·Chemico-biological Interactions·Yan-Ni WangHua Miao
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Thomas IttoopSethu Reddy
Sep 1, 2020·Current Opinion in Chemical Biology·Jasmine M M Pople, Justin M Chalker
Jun 15, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi LiuZongbao Wang
Aug 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenwei XuYaoming Xue
Nov 8, 2018·International Journal of Biological Macromolecules·Yunes PanahiAli A Moosavi-Movahedi
May 29, 2021·Archives of Physiology and Biochemistry·Chang GuoGuoyue Yuan
Jun 20, 2021·Clinical and Experimental Nephrology·Ningmin ZhaoPeizhi Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physiological Reviews
Josephine M Forbes, Mark E Cooper
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Runzhi ZhuQinglong Guo
© 2022 Meta ULC. All rights reserved