Diabetic neuropathy: electrophysiological and morphological study of peripheral nerve degeneration and regeneration in transgenic mice that express IFNbeta in beta cells

Muscle & Nerve
Anna SerafínMartí Pumarola

Abstract

Diabetic neuropathy is one of the most frequent complications in diabetes but there are no treatments beyond glucose control, due in part to the lack of an appropriate animal model to assess an effective therapy. This study was undertaken to characterize the degenerative and regenerative responses of peripheral nerves after induced sciatic nerve damage in transgenic rat insulin I promoter / human interferon beta (RIP/IFNbeta) mice made diabetic with a low dose of streptozotocin (STZ) as an animal model of diabetic complications. In vivo, histological and immunohistological studies of cutaneous and sciatic nerves were performed after left sciatic crush. Functional tests, cutaneous innervation, and sciatic nerve evaluation showed pronounced neurological reduction in all groups 2 weeks after crush. All animals showed a gradual recovery but this was markedly slower in diabetic animals in comparison with normoglycemic animals. The delay in regeneration in diabetic RIP/IFNbeta mice resulted in an increase in active Schwann cells and regenerating neurites 8 weeks after surgery. These findings indicate that diabetic-RIP/IFNbeta animals mimic human diabetic neuropathy. Moreover, when these animals are submitted to nerve crush they have ...Continue Reading

References

May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B HengererH Thoenen
Jul 1, 1988·Annals of Neurology·G SobueD Pleasure
Jan 1, 1984·Annals of Neurology·M J Brown, A K Asbury
Jan 1, 1995·The Journal of Hand Surgery·M ChammasY Allieu
Mar 1, 1995·Journal of the Neurological Sciences·C Ryle, M Donaghy
Aug 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·W F HauptG Pawlik
Jun 1, 1996·Neuroscience Research·C Ide
Mar 14, 1998·Acta Neuropathologica·A P MizisinH C Powell
Jun 20, 1998·The Journal of Biological Chemistry·M PelegrinF Bosch
May 11, 2000·Acta Neuropathologica·J L BradleyP K Thomas
May 31, 2001·Journal of Neuropathology and Experimental Neurology·D LevyD W Zochodne
Oct 9, 2001·Journal of Neuropathology and Experimental Neurology·G Xu, A A Sima
Jun 26, 1965·Lancet·P K THOMAS, R G LASCELLES
Nov 20, 2003·Cellular and Molecular Life Sciences : CMLS·A A F Sima
Jan 7, 2004·Journal of the Neurological Sciences·Rebecca E Hill, Pamela E Williams
Feb 12, 2004·Journal of the Peripheral Nervous System : JPNS·Gina M LeinningerEva L Feldman
May 14, 2004·Journal of the Neurological Sciences·Nigel A Calcutt
Jun 24, 2004·Reviews in Endocrine & Metabolic Disorders·Andrea M Vincent, Eva L Feldman
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·James M Kennedy, Douglas W Zochodne
Feb 23, 2007·Diabetes/metabolism Research and Reviews·Douglas W ZochodneMohammed Bangash
Sep 7, 2007·Neurobiology of Disease·Kelli A SullivanEva L Feldman
Nov 29, 2007·Journal of the Peripheral Nervous System : JPNS·Kaare Severinsen, Johannes Jakobsen
Jul 29, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·D W ZochodneC Toth

❮ Previous
Next ❯

Citations

Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed EddouksNaoufel Ali Zeggwagh
Aug 29, 2013·Journal of Diabetes Research·Md Shahidul Islam
Feb 9, 2012·The Journal of Trauma and Acute Care Surgery·Chun-Hsu YaoYueh-Sheng Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.