Diabetic Retinal and Choroidal Edema in SDT Rats

Journal of Diabetes Research
Fumihiko ToyodaAkihiro Kakehashi

Abstract

We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies. The mean retinal and choroidal thicknesses were significantly thicker in the SDT rats than in the normal SD rats. The choroidal thickness was correlated strongly with the retinal thickness in both rat models. Diabetic retinopathy (DR) and diabetic choroidopathy appeared as edema in the SDT rats. The retinal thickness was correlated strongly with the choroidal thickness in the SDT rats, which is an ideal animal model of both DR and choroidopathy.

References

Jul 27, 2001·International Journal of Experimental Diabetes Research·M ShinoharaY Kanazawa
Jul 20, 2004·The British Journal of Ophthalmology·T NagaokaA Yoshida
Apr 25, 2013·Investigative Ophthalmology & Visual Science·Jee Taek KimYoung Hee Yoon
May 4, 2013·Investigative Ophthalmology & Visual Science·Ji Ho YangSeung Young Yu
Apr 8, 2014·Clinical Ophthalmology·Erkan UnsalHülya Güngel
May 23, 2014·Investigative Ophthalmology & Visual Science·Anna ÉnzsölyÁkos Lukáts
Sep 13, 2014·Journal of Diabetes Research·Fumihiko ToyodaAkihiro Kakehashi

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Citations

Apr 12, 2018·Current Eye Research·Ashutosh JnawaliLisa A Ostrin
Sep 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Noriko HiramatsuNoriaki Nagai
Apr 2, 2020·International Journal of Molecular Sciences·Shou OosukaTsunehiko Ikeda
Mar 25, 2018·Microscopy Research and Technique·Xue-Huan LiuZhen-Chang Wang
Oct 23, 2019·Journal of Diabetes Research·Yoshiaki TanakaAkihiro Kakehashi
Dec 28, 2017·Journal of Agricultural and Food Chemistry·José Antonio González-CorreaJosé Pedro De La Cruz

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Methods Mentioned

BETA
transmission electron microscopy

Software Mentioned

Excel Tokei
ImageJ

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