Diabetic Retinopathy as a Risk Factor for Chronic Kidney Disease Progression: A Multicenter Case⁻Control Study in Taiwan

Nutrients
Hsin-Ting LinYuh-Feng Lin

Abstract

It has rarely been studied whether the presence and severity of diabetic retinopathy (DR) could influence the renal disease progression among all chronic kidney disease (CKD) diabetic patients. This study investigates the characteristics of diabetic patients, with different stages of chronic kidney disease (CKD), according to the occurrence of diabetic retinopathy and determines the influence of retinopathy in the deterioration of renal function. We conduct a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of the CKD project (2008⁻2013) and the National Health Insurance Research Database (NHIRD) (2001⁻2013). A total of 4050 diabetic patients with CKD, 20⁻85 years of age, from 14 hospitals and the community are included in this study. As compared to CKD patients without DR, CKD patients with DR have a lower baseline estimated glomerular filtration rate (eGFR) (39.17 ± 30.36 mL/min per 1.73 m² vs. 54.38 ± 33.67 mL/min per 1.73 m² ); poorer glycemic control (higher glycated hemoglobin (HbA1c) 7.85 ± 4.97 vs. 7.29 ± 4.02, p < 0.01); higher proteinuria (urine protein-to-creatinine ratio (UPCR )1.94 ± 2.96 g/dL vs. 0.91 ± 2.11 g/dL, p < 0.01); more anemia (Hb 11.22 ± 2.43 g/dL vs. 12.39 ...Continue Reading

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Citations

Dec 23, 2020·Investigative Ophthalmology & Visual Science·Jianyong WangYunxian Yu
Nov 16, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Marc EvansUmesh Dashora
Dec 31, 2020·Journal of Clinical Medicine·Shi-Chue HsingWen-Hui Fang
Sep 17, 2021·Journal of Diabetes Investigation·Jun-Sing WangUNKNOWN Diabetes Kidney Disease Research Committee of the Diabetes Association of the Republic of China (Taiwan)

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Methods Mentioned

BETA
biopsies

Software Mentioned

SAS

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