PMID: 22352446Feb 23, 2012Paper

Diabetic retinopathy: current and new treatment options

Current Diabetes Reviews
Gian Paolo Giuliari

Abstract

Diabetes mellitus has become a major health concern worldwide and its incidence is projected to increase. Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are considered the most sight-threatening ocular complications in these patients. Pivotal studies, such as the Early Treatment Diabetic Retinopathy Study (ETDRS) and the Diabetic Retinopathy Study (DRS), have established macular and pan-retinal laser as the gold-standard of treatment for these complications. The recent discovery of the vascular endothelial growth factor (VEGF) and its role in the development of proliferative disease, has led to a movement towards treating PDR and DME with anti-angiogenic medications alone or in conjunction with the gold-standard of care. Due to the severity of the diabetic ocular complications and the rising incidence of diabetes worldwide, it is important for the non-ophthalmologist care provider to be informed of the new treatments available for these conditions in an effort to better guide their patients. In this review, I will discuss the importance of these new methods of treatment as well as the significance of systemic glucose control, vitreous surgery and laser photocoagulation.

Citations

Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Klaus PollingerAchim Goepferich
Oct 10, 2012·British Journal of Clinical Pharmacology·Robert Gábriel
Mar 16, 2016·Toxins·Nancy Scardua BindaMarcus Vinicius Gomez
Jul 1, 2014·Clinical & Experimental Ophthalmology·Godfrey J QuinMark C Gillies
Feb 11, 2015·Cell Biochemistry and Biophysics·Peipei Zhang, Zhanyu Zhou
Jun 25, 2014·Translational Vision Science & Technology·Machelle T ParduePeter M Thulé
May 20, 2016·Journal of Ethnopharmacology·Lingyu ZhouLili Ji
Feb 12, 2014·The British Journal of Ophthalmology·Roderick O'DayDaniel Barthelmes
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Dec 5, 2020·Journal of Diabetes Research·Wenjun ShaLigang Zhou
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