PMID: 15248828Jul 14, 2004Paper

Diabetic retinopathy in two patients with congenital IGF-I deficiency (Laron syndrome)

European Journal of Endocrinology
Z Laron, Dov Weinberger

Abstract

Animal and clinical studies have shown that excessive amounts of growth hormone or insulin-like growth factor-I (IGF-I) promote the development of diabetes and diabetic retinopathy. Forthwith, we present two patients with congenital IGF-I deficiency who developed type II diabetes and subsequently retinopathy. Eighteen adult patients with classical Laron syndrome (8 males, 10 females, aged 20-62 years) were followed by us since childhood or underwent fundus photography with a Nikon NF 505 instrument. Three had been treated in childhood with IGF-I, the rest were never treated, including the two patients reported. Two never-treated patients were diagnosed with type II diabetes (DM) at ages 39 and 41 respectively. There was no diabetes in the families. Oral treatment was followed by insulin injections. Metabolic control was not optimal and one patient developed proliferative diabetic retinopathy, necessitating laser surgery. He also has nephropathy and severe neuropathy. The other patient has background diabetic retinopathy and has developed, progressively, exudates, microaneurisms, hemorrhages and clinically significant macular edema. He also has subacute ischemic heart disease. Our findings show that congenital IGF-I deficiency, ...Continue Reading

Citations

Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
Jul 13, 2011·Journal of Medical Case Reports·Oana R CottaSalvatore Cannavò
Jan 7, 2016·Journal of Translational Medicine·G A AguirreI Castilla-Cortazar
Sep 25, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Zvi Laron
Jan 16, 2009·Diabetes/metabolism Research and Reviews·Swapnil N RajpathakHoward D Strickler
Nov 5, 2011·European Journal of Clinical Investigation·Harn-Shen ChenShu-Hsia Lin
Sep 14, 2011·IUBMB Life·Jakob TriebelCarmen Clapp
Apr 25, 2006·Journal of Diabetes and Its Complications·Gail M SeigelDouglas N Ishii
Sep 14, 2007·Ophthalmic Research·Satagopan UthraGovindasamy Kumaramanickavel
Feb 27, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M ShechterZ Laron
Jun 5, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sebahat Yılmaz AgladıogluZehra Aycan
Sep 24, 2020·Reviews in Endocrine & Metabolic Disorders·Zvi Laron, Haim Werner
Aug 2, 2019·Asia-Pacific Journal of Ophthalmology·Premnath RamanAnish Behl

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