Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities

Current Protocols in Mouse Biology
Alexander VeenstraTimothy S Kern

Abstract

Diabetic retinopathy is a major cause of visual impairment, which continues to increase in prevalence as more and more people develop diabetes. Despite the importance of vision, the retina is one of the smallest tissues in the body, and specialized techniques have been developed to study retinopathy. This article summarizes several methods used to (i) induce diabetes in mice, (ii) maintain the diabetic animals throughout the months required for development of typical vascular histopathology, (iii) evaluate vascular histopathology of diabetic retinopathy, and (iv) quantitate abnormalities implicated in the development of the retinopathy.

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Citations

Apr 18, 2019·Investigative Ophthalmology & Visual Science·Haitao LiuTimothy S Kern
Mar 7, 2018·Hepatology Communications·Eduardo H GilglioniRonald P J Oude Elferink
Jun 2, 2016·Current Protocols in Nucleic Acid Chemistry·Martin Egli
Jan 8, 2020·PloS One·Christian SteuweHans Van Oosterwyck
May 21, 2020·International Journal of Molecular Sciences·Thomas E ZapadkaPatricia R Taylor
Aug 6, 2020·International Journal of Molecular Sciences·Diana R GutsaevaManuela Bartoli
Mar 28, 2019·Journal of Cellular Physiology·Tahereh FarkhondehBabak Roshanravan
Feb 12, 2020·Acta Neuropathologica·Haoshen ShiMaya Koronyo-Hamaoui
Nov 25, 2020·Acta Neuropathologica Communications·Haoshen ShiMaya Koronyo-Hamaoui
Oct 15, 2020·International Journal of Molecular Sciences·Hu Huang
Jan 25, 2020·Neurobiology of Disease·Christina ThebeauRithwick Rajagopal
Nov 15, 2020·Progress in Retinal and Eye Research·Deoye Tonade, Timothy S Kern
May 1, 2021·International Journal of Molecular Sciences·Thomas E ZapadkaPatricia R Taylor

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