Apr 30, 2020

Does hippocampal volume explain performance differences on hippocampal-dependent tasks?

BioRxiv : the Preprint Server for Biology
I. A. ClarkEleanor A Maguire


Marked disparities exist across healthy individuals in their ability to imagine scenes, recall autobiographical memories, think about the future and navigate in the world. The importance of the hippocampus in supporting these cognitive functions has prompted the question of whether differences in hippocampal grey matter volume could be one source of performance variability. Evidence to date has been somewhat mixed. In this study we sought to mitigate issues that commonly affect these types of studies. Data were collected from a large sample of 217 young, healthy adult participants, including whole brain structural MRI data (0.8mm isotropic voxels) and widely-varying performance on scene imagination, autobiographical memory, future thinking and navigation tasks. We found little evidence that hippocampal grey matter volume was related to task performance. This was the case using different analysis methods (voxel-based morphometry, partial correlations), when whole brain or hippocampal regions of interest were examined, and across different sub-groups (divided by gender, task performance, self-reported ability). Hippocampal grey matter volume may not, therefore, significantly influence performance on tasks known to require the hip...Continue Reading

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Biological Markers
Drivers of Vehicles
Systems Biology

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