Diacerein: a potential therapeutic drug for periodontal disease

Medical Hypotheses
Ren-Yeong HuangYi-Shing Shieh

Abstract

Periodontal diseases are chronic inflammatory diseases characterized by the destruction of the tooth-supporting structures. They are the most prevalent form of bone pathology in humans and act as a modifying factor of the systemic health of patients. Accumulating evidence has provided insight into mechanisms of periodontal inflammation revealing that oral pathogens induce inflammatory cascades, including a variety of cytokines produced by different cell types, which promotes host-mediated tissue destruction. Cytokine networks established in diseased periodontal tissues are extremely complex, and substances regulating immuno-inflammatory reactions and signaling pathways, in addition to traditional periodontal treatment, could potentially be targeted as an approach for prevention and treatment of periodontal diseases. Diacerein, a purified anthraquinone derivative, was derived originally from plants with profound anti-inflammatory and analgesic activities. Its wide range of biological activities have been applied and discussed for several decades; however, studies of diacerein have mainly concentrated on effects on joint-derived tissues/cells, which suggest a beneficial role in osteoarthritis treatment. Diacerein reduces associat...Continue Reading

References

May 12, 2000·Osteoarthritis and Cartilage·F MoldovanJ Martel-Pelletier
Nov 16, 2001·Current Rheumatology Reports·G Falgarone, M Dougados
Mar 1, 2003·Journal of Periodontal Research·Rok GaspersicUros Skaleric
Apr 25, 2003·Journal of Periodontology·D T Graves, D Cochran
Sep 4, 2008·Journal of Periodontology·David L Cochran
Mar 5, 2010·European Journal of Immunology·Charles A Dinarello
Apr 22, 2010·Journal of Indian Society of Periodontology·Yogesh Prakash WaykoleMaya Mhaske

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Citations

Jan 1, 2016·Proteome Science·Emanuela MonariCarlo Bertoldi
Mar 21, 2013·Journal of Clinical Periodontology·Carlo BertoldiEmanuela Monari
Oct 16, 2016·International Journal of Dentistry·Jefferson Soares de OliveiraDaniel Fernando Pereira Vasconcelos
Aug 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marwa M M Refaie, Maram El-Hussieny

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