Diacetylenic isobutylamides of Echinacea: synthesis and natural distribution

Phytochemistry
Lankun WuEve S Wurtele

Abstract

The syntheses of three diacetylenic isobutylamides of Echinacea angustifolia have been achieved by direct synthetic routes by way of a common intermediate. The key step is the alkylation of the anion of the silylated diacetylene. We report the presence of all three diacetylenic isobutylamides in six of the nine Echinacea species: E. angustifolia, E. sanguinea, E. simulata, E. tennesseensis, E. atrorubens and E. laevigata. The accumulation of these amides is sensitive to organ type and age.

References

Jul 2, 1999·Phytochemistry·R S RamsewakM G Nair
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Shannon E BinnsBernard R Baum
Jun 27, 2002·Journal of Agricultural and Food Chemistry·Li SunBuncha Ooraikul
Aug 1, 1989·Planta medica·R Bauer, P Remiger

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Citations

Jan 4, 2007·Journal of Agricultural and Food Chemistry·Yi Liu, Patricia A Murphy
Aug 19, 2007·Journal of Agricultural and Food Chemistry·Carlie A LaLoneDiane F Birt
Apr 9, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·David S SenchinaM Ann Perera
May 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dustin A McCannDavid S Senchina
Sep 25, 2007·Journal of Medicinal Food·Zili ZhaiJoan E Cunnick
Nov 1, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·George A KrausEve Wurtele
Sep 14, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·George A KrausEve Wurtele
Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Masayoshi YamadaDaisuke Uemura
Nov 6, 2010·Bioorganic & Medicinal Chemistry Letters·Dongyun ShinChu Won Nho
Mar 24, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zili ZhaiJoan E Cunnick
Feb 1, 2006·Angewandte Chemie·Annabelle L K Shi Shun, Rik R Tykwinski
Aug 9, 2016·The Plant Journal : for Cell and Molecular Biology·Ludmila RizhskyBasil J Nikolau
Apr 20, 2011·The Journal of Organic Chemistry·Nicholas J MatovicJames J De Voss

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