Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle

Journal of Dairy Science
G ConteP Secchiari

Abstract

Several lipogenic genes have been shown to have effects on lipid metabolism: stearoyl CoA desaturase 1 (SCD1) catalyzes the desaturation of several fatty acids (FA) in the cis-Delta(9) position in mammary glands of ruminant animals, diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol synthesis in the mammary gland, and sterol regulatory element binding protein (SREBP-1) is a transcription factor that regulates expression levels of the SCD1 gene and other genes relevant to lipid and FA metabolism in adipose tissue and mammary gland. In this work, 351 Italian Brown cows were genotyped for polymorphisms in the SCD1, SREBP-1, and DGAT1 genes to reveal the allelic distribution in the population. Subsequently, effects on individual milk FA composition and on cis-9 unsaturated/saturated FA ratios, a proxy of mammary stearoyl CoA desaturase activity, were investigated. The genotypes of SCD1 (A293V) and DGAT1 (K232A) were determined by an approach based on the ligation detection reaction and a universal array, whereas the genotype of SREBP-1 (84-bp insertion-deletion) was revealed by PCR amplification of intron 5. The genotype analysis showed an unbalanced distribution of alleles within all genes, being the allel...Continue Reading

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Citations

Mar 12, 2013·The Journal of Dairy Research·Cinzia MarchitelliBianca Moioli
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·K J ShingfieldN D Scollan
May 17, 2011·BMC Genetics·Aniek C BouwmanJohan A M van Arendonk
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Nov 7, 2019·Animals : an Open Access Journal From MDPI·Giovanni SavoiniGuido Invernizzi
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Jun 3, 2021·Animals : an Open Access Journal From MDPI·Serena TuminoBernardo Valenti
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