PMID: 9422608Jan 9, 1998Paper

Diacylglycerol kinase is involved in regulation of expression of the lantibiotic mutacin II of Streptococcus mutans

Journal of Bacteriology
P ChenP W Caufield

Abstract

Genetic characterization of a Tn916 transposon mutant, Streptococcus mutans T8-1, defective in mutacin II production, revealed that the transposon was inserted into the 3' region of a diacylglycerol kinase (dgk) gene. The insertion occurred in the same region as described for another S. mutans mutant, GS5Tn1, which was altered in its ability to respond to environmental stress (Y. Yamashita, T. Takehara, and H. K. Kuramitsu, J. Bacteriol. 175:6220-6228, 1993). Quantitative primer extension from the mutacin structural gene mutA showed a decreased level (about eightfold) of mutA transcription for mutant T8-1. Mutacin production was restored by transforming mutant T8-1 with integration vector pVA891 containing an intact dgk gene. These data indicated that the full-length dgk gene product along with the mutacin biosynthetic operon are required for the production of the mutacin II lantibiotic.

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Citations

Nov 27, 2002·Applied and Environmental Microbiology·Akihiro Yoshida, Howard K Kuramitsu
Jun 20, 2007·Nihon saikingaku zasshi. Japanese journal of bacteriology·Akihiro Yoshida
Mar 10, 2019·Scientific Reports·Kristin MöbiusClemens Glaubitz
Jun 13, 2020·Microbiology Resource Announcements·Indranil Biswas
Feb 28, 2004·FEMS Microbiology Letters·Thomas HindréAlain Dufour
Nov 14, 2006·FEMS Microbiology Reviews·Alain DufourJean-Paul Le Pennec
Jan 10, 2012·Annual Review of Biophysics·Wade D Van Horn, Charles R Sanders
May 7, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Guillaume ManatThierry Touzé
Dec 5, 2017·Bioscience, Biotechnology, and Biochemistry·Naoki Kawakami, Shingo Fujisaki
May 31, 2007·The Journal of Biological Chemistry·Agoston JergaCharles O Rock
Mar 23, 2011·Nature Chemical Biology·Sandra J UllrichClemens Glaubitz

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