PMID: 8596735Mar 1, 1996Paper

Diadenosine polyphosphate-induced inhibition of cardiac KATP channels: operative state-dependent regulation by a nucleoside diphosphate

Pflügers Archiv : European journal of physiology
A JovanovicA Terzic

Abstract

It has been proposed that the regulatory action of mononucleotides, such as ATP and UDP, on cardiac ATP-sensitive K+ (KATP) channels is determined by the state of the channel. Recently, dinucleotides, such as diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A), have been recognized as novel intracellular ligands of cardiac KATP channels. However, it is not known whether the state of KATP channels also determines the response of the channel to dinucleotides. Therefore, we examined the action of diadenosine polyphosphates on KATP channel activity during different operative channel states, using the inside-out patch clamp technique applied to patches excised from guinea-pig ventricular myocytes. Spontaneous openings of KATP channels (or operative condition 1) were inhibited by Ap4A and Ap5A. Addition of UDP, which on its own did not affect spontaneous openings of KATP channels, prevented Ap4A and Ap5A to inhibit spontaneous KATP channel activity. In contrast, following "run-down" of spontaneous channel activity, UDP induced KATP channel openings (or operative condition 2), but could no longer antagonize the inhibitory effect of Ap4A and Ap5A. We conclude that the inhibitory action of diadenosine polyphosphates ...Continue Reading

References

Jan 1, 1990·Cellular Signalling·S J Ashcroft, F M Ashcroft
Jun 1, 1995·Journal of Pharmacological and Toxicological Methods·M D Baxi, J K Vishwanatha
Jan 1, 1994·Journal of Cardiovascular Pharmacology·I Findlay
Jan 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·A JovanovicA Terzic

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Citations

Apr 29, 1998·European Journal of Pharmacology·A JovanovićL Grbović
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·N D'hahanM Vivaudou
Mar 7, 1998·The Journal of General Physiology·A E AlekseevA Terzic
Dec 19, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Ksenia B PustovitDenis V Abramochkin
Feb 16, 2005·British Journal of Pharmacology·Miroslawa Szczepańska-KonkelStefan Angielski
Apr 30, 1998·Journal of the American College of Cardiology·P A Brady, A Terzic
May 2, 2009·Biochimica Et Biophysica Acta·Sofija JovanovićAleksandar Jovanović
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J LuoH Schlüter
May 12, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Dzeja, A Terzic

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