PMID: 9163337Apr 15, 1997Paper

Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules

The Biochemical Journal
M EdgecombeM J Fisher

Abstract

Diadenosine polyphosphates released into the extracellular environment influence a variety of metabolic and other cellular activities in a wide range of target tissues. Here we have studied the impact of these novel nucleotides on gluconeogenesis in isolated rat proximal tubules. Gluconeogenesis was stimulated following exposure of isolated proximal tubules to a range of adenine-containing nucleotides including ADP, ATP, Ap3A, Ap4A, Ap5A and Ap6A. The concentration-dependence of ATP-, Ap3A- and Ap4A-mediated stimulation of gluconeogenesis was similar and was consistent with a role for these agents in the physiological control of renal metabolism. Nucleotide-stimulated gluconeogenesis was diminished in the presence of agents that interfere with phospholipase C activation or intracellular Ca2+ metabolism, indicative of a role for polyphosphoinositide-mediated Ca2+ mobilization in the mechanism of action of ATP, Ap3A and Ap4A. The characteristics of binding of [2-3H]Ap4A to renal plasma-membrane preparations suggest that Ap4A mediates its effects on proximal tubule gluconeogenesis via interaction with P2y-like purinoceptor(s) also recognized by extracellular ATP.

Citations

Nov 30, 1998·Chemistry & Biology·F HuangM Yarus
May 8, 2001·Clinical and Experimental Pharmacology & Physiology·E W Inscho
Nov 23, 2013·Purinergic Signalling·Geoffrey BurnstockMatthew A Bailey
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Aug 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sang Gyu ParkSunghoon Kim
May 16, 2001·American Journal of Physiology. Renal Physiology·E W Inscho
Jun 28, 2000·Journal of the Autonomic Nervous System·M A BaileyR J Unwin
Jul 31, 2002·Archives of Biochemistry and Biophysics·Adam K JagielskiJadwiga Bryła

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