Diadenosine polyphosphates' action on calcium and vessel contraction

American Journal of Hypertension
M TepelW Zidek

Abstract

The effects of the endogenous, platelet-derived vasoactive compounds, diadenosine tetraphosphate (AP4A), diadenosine pentaphosphate (AP5A), and diadenosine hexaphosphate (AP6A) on the vasoconstriction of isolated rat renal resistance vessels and rat aortic strips were measured using a vessel myograph. In addition, the effects of AP4A, AP5A, and AP6A on the cytosolic free calcium concentration ([Ca2+]i) were evaluated in cultured rat vascular smooth muscle cells (VSMC) using the fluorescent dye technique. Diadenosine polyphosphates dose-dependently increased the force of renal resistance vessels and isolated aortic strips. The administration of 10 mumol/L AP4A, AP5A, or AP6A significantly increased the force of isolated renal resistance vessels by 3.48+/-0.43 mN (n = 8), 2.14+/-0.40 mN (n = 12), or 2.70+/-0.31 mN (n = 11, each P < .01 compared with resting tension), respectively. The administration of 10 micromol/L AP4A, AP5A, or AP6A significantly increased the force of isolated aortic strips by 2.45+/-0.97 mNewton (n = 10), 2.70+/- 0.30 mN (n = 6), or 1.48+/-0.20 mN (each P < .01 compared with resting tension), respectively. The administration of 10 micromol/L AP4A, AP5A, or AP6A significantly increased [Ca2+]i in VSMC to a pe...Continue Reading

Citations

May 16, 2001·American Journal of Physiology. Renal Physiology·E W Inscho
May 8, 2001·Clinical and Experimental Pharmacology & Physiology·E W Inscho
Jul 1, 2009·British Journal of Pharmacology·Vera JankowskiJoachim Jankowski
Aug 28, 2009·Seminars in Dialysis·Vera JankowskiJoachim Jankowski
Jun 9, 2000·Kidney International·G GabriëlsM Steinhausen
Jul 31, 2002·Biochemical Pharmacology·Luminita H PojogaRichard H Hilderman

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