Diagnosing a solitary pulmonary nodule using multiple bronchoscopic guided technologies: A prospective randomized study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Liyan BoFaguang Jin

Abstract

The rate of detection of pulmonary nodules on computed radiography (CR) is approximately 0.09-0.2%, so rapid identification of the nature of solitary pulmonary nodules (SPNs) with a likelihood of malignancy is a critical challenge in the early diagnosis of lung cancer. We conducted this study to compare the diagnostic yield and safety of endobronchial ultrasonography with a guide sheath (EBUS-GS), and the combination of EBUS-GS and virtual bronchoscopic navigation (VBN). This was a prospective, multicenter, multi-arm, randomized controlled trial involving a total of 1010 subjects. All the patients recruited underwent a chest CT scan which found SPNs that needed to be diagnosed. The subjects were randomly divided into one of three groups: a traditional, non-guided, bronchoscopy biopsy group (NGB group), an EBUS-GS guided bronchoscopy biopsy group (EBUS group), and a guided bronchoscopy biopsy group that combined EBUS-GS with VBN (combined group). The primary endpoint was to investigate the differences between the diagnostic yields of the three groups. There was no significant difference in the diagnostic yield between the EBUS group (72.3%) and the combined group (74.3%), but the diagnostic yield for the NGB group was 41.2%. The...Continue Reading

Citations

Nov 26, 2019·Expert Review of Respiratory Medicine·Tae Jung KimKyung Soo Lee
Feb 28, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·David Fielding, Masahide Oki

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