PMID: 11339995May 8, 2001Paper

Diagnosing acute liver graft rejection: experimental application of an implantable telemetric impedance device in native and transplanted porcine livers

Biosensors & Bioelectronics
J HarmsR Busch

Abstract

Diagnosis of acute rejection is a complex and persistent problem in liver transplantation. Focused on the use of proprietary impedance technology a porcine liver model was designed to provide immediate information for differentiation of normal and acute rejecting tissue by an implantable telemetric device. Electrical impedance was analyzed by electrodes implanted in vitro and in vivo in the liver of pigs, where impedance is derived from measurements of voltage transients produced in response to programmed current pulses. Consequent electric recordings in porcine livers after transplantation and after mere laparotomy were evaluated in relation to biochemical parameters and histological results of liver biopsies. Acute rejection was correctly predicted in all cases and correctly excluded in the remaining 32 biopsy related impedance recordings (P<0.004). Impedance measurements not only correlated with the diagnosis from liver biopsy specimen (r=0.84, P<0.0001) but also exemplified the severity of histological acute rejection. Impedance analysis reveals evident physiologic relation of acute liver graft rejection and electrical organ properties. Electrodes implanted in transplanted porcine livers allow running less invasive monitori...Continue Reading

References

Jun 1, 1985·Transplantation·J W WilliamsR C Haggitt
Apr 1, 1968·The Journal of Surgical Research·J TerblancheK E Hobbs
Jun 1, 1971·The British Journal of Surgery·D M DentJ Terblanche
Sep 1, 1993·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·K J OldhaferH U Spiegel
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·Y KonishiY Monden
Jun 18, 1999·Transplantation Proceedings·S De Geest, J Vanhaecke

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Citations

Dec 18, 2012·Physiological Measurement·Paco Bogónez-FrancoJavier Rosell-Ferrer

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