Diagnosing and grading heart failure with tomographic perfusion lung scintigraphy: validation with right heart catheterization

ESC Heart Failure
Jonas JögiHåkan Arheden

Abstract

Pulmonary congestion remains a diagnostic challenge in patients with heart failure (HF). The recommended method, chest X-ray (CXR), lacks in accuracy, whereas quantitative tomographic lung scintigraphy [ventilation/perfusion single-photon emission computed tomography (V/P SPECT)] has shown promising results but needs independent validation. The aim of this study is to evaluate V/P SPECT as a non-invasive method to assess and quantify pulmonary congestion in HF patients, using right heart catheterization as reference method. The secondary objective was to investigate the performance of V/P SPECT in the clinical setting compared with CXR. Forty-six consecutive patients with HF that were under consideration for heart transplantation were studied prospectively. All participants were examined with V/P SPECT, CXR, and right heart catheterization. Pulmonary artery wedge pressure served as reference method. Quantitative perfusion gradients were derived from V/P SPECT images. Ventilation/perfusion single-photon emission computed tomography images were also assessed both by expert readers and clinical nuclear medicine physicians. Expert readers correctly identified 87% of all patients with an elevated pulmonary artery wedge pressure > 15...Continue Reading

References

Jul 1, 1988·Journal of Thoracic Imaging·M PistolesiC Giuntini
Aug 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·D L Gilday, A E James
May 12, 2000·Journal of the American College of Cardiology·H Kataoka, S Takada
Jun 30, 2009·European Journal of Nuclear Medicine and Molecular Imaging·M BajcUNKNOWN EANM Committee
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jonas JögiMarika Bajc

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Citations

Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marika BajcBjorn Jonson
Oct 9, 2020·Circulation. Cardiovascular Imaging·Mariam Al-MashatJonas Jögi
Feb 21, 2021·The Canadian Journal of Cardiology·Yukina HirataMasataka Sata

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Methods Mentioned

BETA
X‐ray

Software Mentioned

Expert Reader
GraphPad Prism
Oasis Pulmogam
SPSS

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