Diagnosing and monitoring cirrhosis: Liver biopsy, hepatic venous pressure gradient and elastography

Gastroenterología y hepatología
Juan G AbraldesAnnalisa Berzigotti

Abstract

In this review we summarize the role of liver biopsy, transient elastography and hepatic venous pressure gradient (HVPG) in the diagnosis and monitoring of patients with liver cirrhosis. Transient elastography is useful for the non-invasive diagnosis of cirrhosis, but relevant information is lost if it is used as a dichotomous test. The development of clinically significant portal hypertension (defined as a hepatic venous pressure gradient ≥ 10 mmHg) is associated with the development of varices and decompensation and it is something that it is worth testing for. Transient elastography has some value for the prediction of clinically significant portal hypertension, but a large proportion of patients have non-diagnostic values. It has also some value for the diagnosis of varices, but non-invasive markers cannot substitute endoscopic screening in cirrhosis. Better dynamic, easily repeatable non-invasive tools are needed to monitor compensated cirrhosis.

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Citations

Dec 2, 2014·Clinics in Liver Disease·Juan G AbraldesPuneeta Tandon
Dec 7, 2013·Gastroenterología y hepatología·Antonio Ojeda, Luis A Moreno
Jun 5, 2013·Gastroenterología y hepatología·Annalisa Berzigotti, Juan G Abraldes
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Klaas Poelstra
Jan 23, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G AbraldesAnnalisa Berzigotti
Jul 7, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Vik Veer, Srikanth Puttagunta
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G AbraldesUNKNOWN Anticipate Investigators
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May 15, 2015·Expert Review of Gastroenterology & Hepatology·Jennifer L Horsley-Silva, Hugo E Vargas
Apr 29, 2021·European Journal of Gastroenterology & Hepatology·Mahmoud A ElkerdawyMohamed H Emara
Jul 31, 2021·World Journal of Gastrointestinal Endoscopy·Giuseppe GrassiLeonardo Baiocchi

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